Vascular Tumors and Developmental Malformations Pathogenic Mechanism
This book comprehensively covers the classification, histopathology, pathogenesis, and molecular diagnosis of vascular tumors and malformations, correlating these with current approaches to clinical management. It offers a new multidisciplinar
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Paula E. North Tara Sander Editors
Vascular Tumors and Developmental Malformations Pathogenic Mechanisms and Molecular Diagnosis
Molecular and Translational Medicine
Series Editors William B. Coleman Gregory J. Tsongalis
More information about this series at http://www.springer.com/series/8176
Paula E. North • Tara Sander Editors
Vascular Tumors and Developmental Malformations Pathogenic Mechanisms and Molecular Diagnosis
Editors Paula E. North Department of Pathology, Division of Pediatric Pathology Medical College of Wisconsin Milwaukee, WI, USA
Tara Sander Department of Pathology, Division of Pediatric Pathology Medical College of Wisconsin Milwaukee, WI, USA
ISSN 2197-7852 ISSN 2197-7860 (electronic) Molecular and Translational Medicine ISBN 978-1-4939-3239-9 ISBN 978-1-4939-3240-5 (eBook) DOI 10.1007/978-1-4939-3240-5 Library of Congress Control Number: 2015956616 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface
Vascular anomalies encompass a dizzying array of distinct clinicopathologic entities that can be grouped, roughly, into two general categories: vascular tumors and developmental vascular malformations. The vascular tumors are intrinsically proliferative lesions, at least in some phase of their inception, and include both benign and malignant neoplasms as well as reactive proliferations. The vascular malformations are more static congenital errors in development of the vasculature that may evolve over time under environmental and/or genetic influences. Many of these anomalies, even those officially “benign,” can be absolutely devastating for patients over the course of a childhood or a lifetime, also placing great burden on families and frustrating healthcare providers who struggle to provide relief. Current mainstream
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