Vinorelbine

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Vinorelbine Cutaneous recall phenomenon in an elderly patient: case report A 78-year-old man with non-small cell lung cancer developed a cutaneous recall phenomenon while receiving vinorelbine. The man received carboplatin and a 10-minute infusion of vinorelbine 25 mg/m2 at a concentration of 0.45 mg/mL in 100mL of sodium chloride, into a vein of his right arm, on day 1 of his first chemotherapy cycle. He developed pain, erythema and swelling on his right forearm on day 7. Treatment with Burow’s solution was initiated based on a diagnosis of phlebitis, and his discomfort and swelling improved. He received a second vinorelbine infusion into a vein of his left arm at the same dose and concentration on day 8. The pain in his right forearm increased on day 11, and was accompanied by marked erythema, swelling and desquamation with an ulceration of about 2.5 × 1cm. Treatment comprised povidone iodine, analgesia and corticosteroids, and the man’s ulceration improved and treatment was continued. Chemotherapy was stopped on day 18 because of non-neutropenic febrile syndrome. Vinorelbine was restarted orally at 60 mg/m2 on day 73 with no complications. The man had remained stable with no sequelae 6 months later [outcome not clearly stated]. Author comment: "The Naranjo score showed probable causality for the association of vinorelbine chemotherapy and the development of a recall phenomenon." Gomez-Ulloa D, et al. Cutaneous recall phenomenon with vinorelbine. Annals of Pharmacotherapy 45: 1168-1169, No. 9, Sep 2011. Available from: URL: http:// 803062390 dx.doi.org/10.1345/aph.1q279 - Spain

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Reactions 12 Nov 2011 No. 1377