Visualisation of aortic flow disturbance in Marfan syndrome by 4D phase-contrast CMR
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POSTER PRESENTATION
Open Access
Visualisation of aortic flow disturbance in Marfan syndrome by 4D phase-contrast CMR Alex Pitcher*, Tom E Cassar, Joseph Suttie, Jane M Francis, Paul Leeson, Edward Blair, B Paul Wordsworth, J Colin Forfar, Saul G Myerson, Michael Markl, Stefan Neubauer, Steffen E Petersen From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011 Objective To characterise the distribution, extent and severity of aortic flow disturbance in the aorta in Marfan syndrome. Background Marfan syndrome commonly leads to progressive aortic dilation and aortic dissection, particularly at the aortic sinuses and descending thoracic aorta. Abnormal blood flow patterns may contribute to the enlargement and dissection of an inherently weak aorta. Methods 15 patients with Marfan syndrome and no history of prior aortic dissection or surgery, and 18 healthy volunteer controls matched for age, sex and height underwent CMR at 3T (Siemens, Erlangen). Time-resolved, 3D velocity-encoded and magnitude data were acquired using a phase contrast CMR sequence (Figure 2). Each dataset was evaluated for flow disturbance by two independent observers, experienced in aortic flow visualisation, and blinded to patient identity. Results Significant vortical flow in any segment (defined as flow disturbance occupying more than one half of the aortic lumen) was present in all patients with Marfan syndrome but in only 7/18 controls (P
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