Aortic dissection: visualisation of aortic blood flow and quantification of wall shear stress using time-resolved, 3D ph
- PDF / 346,525 Bytes
- 2 Pages / 595.276 x 793.701 pts Page_size
- 26 Downloads / 177 Views
POSTER PRESENTATION
Open Access
Aortic dissection: visualisation of aortic blood flow and quantification of wall shear stress using time-resolved, 3D phase-contrast MRI Alex Pitcher1*, Tom E Cassar1, Paul Leeson1, Jane M Francis1, Edward Blair1, Paul B Wordsworth1, J Colin Forfar1, Steffen E Petersen1, Michael Markl2, Stefan Neubauer1 From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011 Background Aortic blood flow in healthy people is characterised by helical flow in the ascending and descending aorta, with corresponding patterns of wall shear stress (WSS) imposed upon the wall of the aorta by moving blood. Flow and WSS patterns in the aortic root and sinuses of Valsalva, and the flow patterns in diseased aortas are incompletely defined. We describe the use of a validated, time-resolved, 3D flow MRI sequence to characterize flow and WSS in the aorta, focusing on the aortic root, and demonstrate the flow and WSS in the aorta of
healthy volunteers and patients with prior aortic dissection.
Methods 10 healthy subjects and 3 patients with a prior history of aortic dissection underwent cardiovascular magnetic resonance imaging at 3T using a time-resolved 3-dimensional flow technique. Flow patterns were visualised as streamlines (Ensight, CEI). WSS quantification was undertaken at predefined aortic locations (Fig. 1a).
Figure 1 Figure 1 a. Orientation of planes for blood flow and wall sheer stress quantification. Fig 1b. 3D flow visualization of a 21 year-old healthy volunteer demonstrating non-helical flow at the aortic annulus, sinuses of Valsalva and sinotubular junction with helical flow in the distal ascending aorta, arch and proximal descending aorta. Fig 1c. 51 year-old male with Loeys-Dietz syndrome due to a novel mutation in the TGF b Receptor gene, with prior aortic valve and root replacement surgery, following Type A aortic dissection showing complex disturbance of flow with complex vortices and helices. Two distinct lumens are seen in the aortic arch, which reunite in the proximal descending aorta to form a pronounced right-handed helical flow jet. 1 Oxford University, Oxford, UK Full list of author information is available at the end of the article
© 2011 Pitcher et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Pitcher et al. Journal of Cardiovascular Magnetic Resonance 2011, 13(Suppl 1):P392 http://jcmr-online.com/content/13/S1/P392
Page 2 of 2
Results All healthy subjects showed retrograde systolic flow jets in the sinuses of Valsalva, with corresponding negative systolic mean axial wall shear stress (-0.22N/m2 ± SD 0.05) at this level compared to positive values at all other aortic levels (e.g. ascending aorta +0.54N/m2 ± SD 0.14, p
Data Loading...
