Vitamin B12 and folic acid levels in pediatric migraine patients
- PDF / 394,928 Bytes
- 4 Pages / 595.276 x 790.866 pts Page_size
- 45 Downloads / 189 Views
ORIGINAL ARTICLE
Vitamin B12 and folic acid levels in pediatric migraine patients Hilal Aydin1 · Ibrahim Hakan Bucak2 · Mehmet Geyik3 Received: 2 May 2020 / Accepted: 4 September 2020 © Belgian Neurological Society 2020
Abstract Migraine is a recurrent, primary cause of headache. Although prophylactic vitamin B12 therapy is used on migraine patients, there is a limited number of studies examining the levels of B12 vitamin and folic acid in pediatric patients diagnosed with migraine. The study group (Group 1) included 65 pediatric patients diagnosed with migraine in the Pediatric neurology outpatient clinic, and 87 healthy cases admitted to the general pediatric clinic were included in the control group (Group 2). Complete blood count parameters, vitamin B12, folic acid, ferritin, and 25 OH D vitamin levels of the study and control groups were compared. The mean vitamin B12 level was 196.42 ± 95.54 pg/mL (59–499) in Group 1 and 240 ± 105.24 pg/ mL (74–619) in Group 2. The mean folic acid level was 8.85 ± 3.49 pg/mL (3.68–23.70) in Group 1 and 7.24 ± 7.17 pg/mL (1.11–35.50) in Group 2. There was a statistically significant difference between Group 1 and 2 in terms of vitamin B12 and folic acid levels (p = 0.008, p = 0.00). The results of this study indicate the requirement for routine evaluation of vitamin B12 and folic acid levels in pediatric patients diagnosed with migraine. Keywords Migraine · Child · Folic acid · Vitamin B12 · Treatment
Introduction Migraine is one of the common neurological disorders in children and adults. The prevalence of migraine in childhood has been reported to be 3% in the age group of 3–7 years and 8–23% in the age group of 11–15 years [1]. Although the exact cause of migraine is unknown, genetic and environmental factors are thought to play a role in the onset of migraine attacks [2]. Mutation of the MTHFR gene, abnormal vitamin D levels, inflammatory agent production around neurons and cerebrospinal fluid, low serotonin levels, increased calcitonin gene-related peptide (CGRP), * Hilal Aydin [email protected] Ibrahim Hakan Bucak [email protected] Mehmet Geyik [email protected] 1
Department of Pediatric Neurology, Faculty of Medicine, Balikesir University, Cayirhisar, 10145 Balikesir, Turkey
2
Department of Pediatrics, Faculty of Medicine, Adiyaman University, 02200 Adiyaman, Turkey
3
Department of Pediatrics, Adiyaman Sincik State Hospital, Adiyaman, Turkey
matrix metalloproteinase 9 (MMP-9) levels, homocysteine and nitric oxide (NO), and mitochondrial dysfunction are among the most significant causes of migraine [2]. Mitigating headache and reducing the frequency of headache are among the primary goals of migraine treatment. Drugs used for migraine treatment include triptans, analgesics, antiepileptic drugs, antidepressants, minerals, vitamins (B2, B3, B12, D), and botulinum toxin A [3–5]. Although prophylactic vitamin B12 therapy is recommended as migraine prophylaxis for pediatric and adolescent patients, there is a limited number of studies exa
Data Loading...
