Voltammetric determination of phentolamine mesylate in pharmaceutical formulations at poly (4-aminobenzene sulfonic acid
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ORIGINAL PAPER
Voltammetric determination of phentolamine mesylate in pharmaceutical formulations at poly (4‑aminobenzene sulfonic acid)‑modified glassy carbon electrode Sen Fan1 · Lei Ji2 · Guoliang Mao2 · Xin Sui2 · Huan Wang2 · Yuanhai Zhu2 · Hua Song2 Received: 12 December 2019 / Accepted: 12 June 2020 © Institute of Chemistry, Slovak Academy of Sciences 2020
Abstract A poly (4-aminobenzene sulfonic acid)-modified glassy carbon electrode (p-ABSA/GCE) was fabricated by electropolymerization. It was found that phentolamine mesylate, an effective and important cardiovascular dilatation drug with low redox activity at the glassy carbon electrode (GCE) can produce a sensitive well-defined anodic peak current at p-ABSA/GCE. Investigation indicated that the oxidation of phentolamine at p-ABSA/GCE was one electron/one proton transfer process which was controlled by adsorption. In optimal conditions, the anodic peak current was linear to the concentrations of phentolamine over the range of 5.0 × 10–7–1.0 × 10–5 M with a detection limit of 2.0 × 10–7 M. The modified electrode showed good stability and reproducibility. The electroanalytical method proposed was successfully applied to the determination of phentolamine mesylate in pharmaceutical formulations. Keywords Phentolamine · Electropolymerization · 4-Aminobenzene sulfonic acid · Modified glassy carbon electrode
Introduction Phentolamine mesylate (PM, Fig. 1) is a non-selective alpha-adrenergic antagonist that can inhibit the action of the adrenergic receptors. It can antagonize epinephrine and norepinephrine, obviously reduce vascular resistance, increase blood volume and improve microcirculation. It is clinically used in the diagnosis of vasospastic diseases, such as acral arterial spasm, cyanosis of hands and feet, infective toxic shock and pheochromocytoma. It is also effective for ventricular premature beats. However, PM has side effects in clinical application. It was found that PM often caused orthostatic hypotension, tachycardia, arrhythmia, nasal obstruction, nausea, vomiting and other adverse reactions. Nowadays the use of PM instead of Viagra to treat erectile dysfunction has become more and more common. * Yuanhai Zhu [email protected] 1
College of Petroleum Engineering, Northeast Petroleum University, Daqing 163318, People’s Republic of China
College of Chemistry and Chemical Engineering, Northeast Petroleum University, Daqing 163318, People’s Republic of China
2
However, the long-term safety of oral PM tablets has been questioned by medical scientists (Ugarte et al. 2002; PadmaNathan et al. 2002). Therefore, it is particularly important to explore a method for quantitative determination of PM with high precision, good accuracy, convenience and rapidity. At present, methods for the determination of PM mainly include various chromatographic procedures, such as high performance liquid chromatography (Webster et al. 2003; Godbillon et al. 1981; Bros et al. 1978), thin-layer chromatography (Mikami et al. 2002), and gas chromatography etc. (Sio
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