William Griffiths, Yuqin Wang (Eds.): Lipidomics: current and emerging techniques
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William Griffiths, Yuqin Wang (Eds.): Lipidomics: current and emerging techniques Martin Giera 1
# Springer-Verlag GmbH Germany, part of Springer Nature 2020
Bibliography Lipidomics: current and emerging techniques William Griffiths, Yuqin Wang (Eds.) Series: New Developments in Mass Spectrometry The R oyal Society o f Chemistry ISBN: 978-1-78801-160-0 Hardcover, 288 pages, 23 January 2020, £169.00
Book’s topic Lipidomics is a very rapidly evolving field. Particularly bioactive lipids, as for example, short-chain fatty acids, the eicosanoids and docosanoids, or fatty acid esters of hydroxyl fatty acids (i.e., FAHFAHs), have sparked increasing interest in lipid biology and analysis during the last decade. However, unlike metabolomics, lipidomics analysis deals with an even higher complexity and minute structural differences, ultimately influencing our understanding of biochemical pathways and phenotypes. These facts have boosted the development of analytical techniques designed to investigate lipids at increasing sensitivity and detail. Today, mass spectrometry plays a central role in lipidomics analysis with novel and emerging developments, as for example, advanced
* Martin Giera [email protected] 1
Center for Proteomics and Metabolomics, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands
ion-mobility applications and imaging mass spectrometry, allowing us to extensively decipher and understand the lipidome and thereby discover novel and exciting lipid biology. Contents The presented book by Griffiths and Wang aims at summarizing and explaining novel and emerging techniques and applications in the field of lipidomics analysis. The book is built on 10 chapters with a total of 288 pages. While the book clearly focuses on novel mass spectrometry–based analysis techniques, the authors did well to include a basic overview of current lipidomics techniques as well as a summary of important multivariate statistics approaches applied in modern lipidomics analysis (chapters #1 and 2). Both chapters are well-written introductions to the topic and can be considered concise descriptions of modern lipidomics approaches. Subsequently, the authors introduce and discuss novel developments in lipid separation and imaging (chapters #3, 4, and 5). Importantly, the authors dedicated individual, focused chapters to “ion mobility-mass spectrometry for lipid analysis” (chapter #4) and “mass spectrometry imaging of lipids” (chapter #5), two emerging fields in lipid analysis. Chapters #6 and 7 are placed at the interface of organic and analytical chemistry, discussing “derivatization for direct infusion- and liquid chromatography-mass spectrometry” (chapter #6) and “unsaturated lipid analysis via coupling the PaternoBüchi reaction with ESI-MS/MS” (chapter #7). While chapter #6 gives a summary of useful derivatization reagents for lipid analysis, chapter #7 dives much more into current challenges and potential solutions introducing the Paterno-Büchi reaction as a possible too
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