Lipidomics Volume 2: Methods and Protocols
Essential in biological functions like cell signaling and, when disturbed, a likely cause of disease, lipids have proven to be a vital force in cell biology. In Lipidomics: Methods and Protocols, an international panel of experts present a wide variety of
- PDF / 11,432,909 Bytes
- 388 Pages / 547.087 x 737.008 pts Page_size
- 18 Downloads / 204 Views
in
Molecular Biology™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For other titles published in this series, go to www.springer.com/series/7651
Lipidomics Volume 2: Methods and Protocols
Edited by
Donald Armstrong University at Buffalo, Buffalo, NY, USA University of Florida, Gainesville, FL, USA
Editor Donald Armstrong University of Buffalo Buffalo, NY, USA and University of Florida Gainesville, FL, USA
The cover image are overlapping snapshots of a single peroxidized lipid, taken from computer stimulations. Peroxidation mofidies the local conformational preferences of acyl chains and increases their mobility, with implications for structural and dynamic properties of the membrane. ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-60761-324-4 e-ISBN 978-1-60761-325-1 DOI 10.1007/978-1-60761-325-1 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2009927725 © Humana Press, a part of Springer Science+Business Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Cover illustration: Snapshots of a single PLPC and a peroxidized analogue (13-tc), taken at 5 ns intervals. Molecules are oriented along the membrane and superimposition was done on the phosphorus and oxygen atoms. Images were obtained from Chapter 18, Vol. 1. Cover design: Karen Schulz Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface Lipidomics is a sub-discipline of metabolomics and is defined as the large-scale study of non-water-soluble metabolites (lipids and lipidome) that utilize system-level analysis to characterize lipids and their interacting moieties (1). A literature search at the end of 2008 showed there were 200 articles published on lipidomics encompassing glycerophospholipids, sphingolipids, polyunsaturated fatty acids, glycolipids, sterol lipids, and proteolipids. It has been predicted that the combination of these lipid classes
Data Loading...
