Zinc, Copper, and Selenium Tissue Levels and Their Relation to Subcutaneous Abscess, Minor Surgery, and Wound Healing in
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Zinc, Copper, and Selenium Tissue Levels and Their Relation to Subcutaneous Abscess, Minor Surgery, and Wound Healing in Humans Ursula Mirastschijski & Alicia Martin & Lars N. Jorgensen & Barry Sampson & Magnus S. Ågren
Received: 21 September 2012 / Accepted: 27 March 2013 / Published online: 18 April 2013 # Springer Science+Business Media New York 2013
Abstract Trace element involvement in wounds left to heal by secondary intention needs clarification. We have previously reported faster healing of wounds following acute surgery compared with elective excision of pilonidal sinus disease. The effect of topical zinc on the closure of the excisional wounds was mediocre compared with placebo. In contrast, parenteral zinc, copper, and selenium combined appear effective for wound healing in humans. We have investigated zinc, copper, and selenium with respect to (a) impact of acute versus chronic pilonidal sinus and (b) regional concentrations within granulating wounds treated topically with placebo or zinc in 42 (33 males) pilonidal disease patients. Baseline serum and skin concentrations of copper correlated (rS =0.351, p=0.033, n=37), but not of zinc or selenium. Patients with abscesses had elevated serum C-reactive protein (CRP) and copper levels (+29 %; U. Mirastschijski : A. Martin : L. N. Jorgensen : M. S. Ågren (*) Department of Surgery K, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark e-mail: [email protected] U. Mirastschijski Department of Plastic, Reconstructive and Aesthetic Surgery, Klinikum Bremen-Mitte and Cooperation Center Medicine, University of Bremen, Bremen, Germany B. Sampson Clinical Biochemistry, Charing Cross Hospital, Imperial College School of Medicine, London, UK M. S. Ågren Copenhagen Wound Healing Center, Bispebjerg Hospital, Copenhagen, Denmark M. S. Ågren Department of Diagnostic Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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