Zinc(II) halide and copper(II) bromide complexes with caffeine: structures, physicochemical properties, and biological a
- PDF / 287,073 Bytes
- 7 Pages / 612 x 792 pts (letter) Page_size
- 69 Downloads / 200 Views
Russian Chemical Bulletin, International Edition, Vol. 69, No. 7, pp. 1394—1400, July, 2020
Zinc(II) halide and copper(II) bromide complexes with caffeine: structures, physicochemical properties, and biological activity* N. S. Rukk,а L. G. Kuzmina,b G. A. Davydova,c G. A. Buzanov,b S. K. Belus,d E. I. Kozhukhova,d V. M. Retivov,d T. V. Ivanova,а V. N. Krasnoperova,a and B. M. Bolotind aMIREA
— Russian Technological University, M. V. Lomonosov Institute of Fine Chemical Technologies, 86 prosp. Vernadskogo, 119571 Moscow, Russian Federation. Fax: +7 (495) 434 9287. E-mail: [email protected] bN. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky prosp., 119991 Moscow, Russian Federation. Fax: +7 (495) 954 1279 cInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 3 Institutskaya ul., 142290 Pushchino, Moscow region, Russian Federation. Fax: +7 (496 7) 33 0553 dInstitute of Chemical Reagents and High Purity Chemical Substances of National Research Center "Kurchatov Institute", 3 Bogorodskii val, 107076 Moscow, Russian Federation. Fax: +7 (495) 963 7071 This study provides a comparative characterization of the structural parameters and cytotoxicity of zinc halide and copper(II) bromide complexes with caffeine (caf) of the composition [Zn(caf)(H2O)X2] (X = Cl, Br, I) and [Cu(caf)2Br2] (1). The cytotoxicity of the complexes is dose-dependent in all cell lines. The concentrations of the complexes, at which they are more cytotoxic against cancer cells (MCF-7) than against stem cells (DPSC), were determined. The synthesized complexes exhibited synergism of cytotoxicity. Key words: zinc(II) halides, copper(II) bromide, caffeine, square-planar structure, molecular complex, cytotoxicity.
According to the World Health Organization (WHO), cancer is the second leading cause of death (after cardiovascular diseases) worldwide, accounting for about 13% of all deaths.1 According to estimates from the International Agency for Research on Cancer (IARC), in 2018 there were 17 million new cancer cases and 9.5 million cancer deaths worldwide, i.e., 26,000 deaths a day.** The continuing global demographic and epidemiologic transitions signal an ever-increasing cancer burden, and cancer rates expected to hit 20 million new cases per year by 2025.1 Hence, a challenging problem is to develop new anticancer agents equally or more effective than platinum-based drugs, which exhibit toxicity, drug resistance, and other adverse side effects.2—5 A major intracellular target of anticancer agents based on transition metal complexes is deoxyribonucleic acid * Based on the materials of the XXI Mendeleev Congress on General and Applied Chemistry (September 9—13, 2019, St. Petersburg, Russia). ** https://www.cancer.org/research/cancer-facts-statistics/ global.html.
(DNA). These drugs cause various DNA damages, blockage of cell division, and cell death. The covalent interaction of small metal complexes with the DNA double helix via intercalation into a DNA molecule followed by
Data Loading...
