Zoledronic acid
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Osteonecrosis of the jaw: case report A 64-year-old woman developed osteonecrosis of the jaw (ONJ) during treatment with zoledronic acid for bone pain. The woman had a history of breast cancer and multiple bone metastases. In December 2004 she was initiated on IV infusions of zoledronic acid 4mg every 28 days. A few months after commencing zoledronic acid she discontinued concomitant analgesics. In October 2006, after 16 infusions of zoledronic acid, she presented with pain in her left lower jaw bone. A CT scan demonstrated an osteolytic lesion with central and peripheral areas of bone sclerosis. A gammagraphic study showed an intense hypercaptation at the left jaw, in addition to that already discovered in the spinal column and skull. The woman underwent surgical excision. As a result she was diagnosed with ONJ due to IV bisphosphonate use. Zoledronic acid was discontinued. One year after the surgery she had minimal residual jaw pain. Alvarez-Busto I, et al. Osteolytic jaw lesion in metastatic breast cancer: not always metastases. New Zealand Medical Journal 120: 84-85, No. 1262, 21 Sep 2007 801083164 Spain
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Reactions 20 Oct 2007 No. 1174
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