1040 Adverse effects of the metabolic deregulation on aortic stiffness and diastolic function in patients with metabolic
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BioMed Central
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Meeting abstract
1040 Adverse effects of the metabolic deregulation on aortic stiffness and diastolic function in patients with metabolic syndrome assessed with magnetic resonance imaging Stijntje D Roes*, Reza Alizadeh Dehnavi, Jos J Westenberg, Hildo J Lamb, Jouke T Tamsma and Albert de Roos Address: Leiden University Medical Center, Leiden, The Netherlands * Corresponding author
from 11th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 1–3 February 2008 Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A165
doi:10.1186/1532-429X-10-S1-A165
Abstracts of the 11th Annual SCMR Scientific Sessions - 2008
Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdfThis abstract is available from: http://jcmr-online.com/content/10/S1/A165 © 2008 Roes et al; licensee BioMed Central Ltd.
Introduction
Results
Previous ultrasound studies demonstrated the adverse effect of the metabolic syndrome (MS) on aortic stiffness and left ventricular (LV) diastolic function. However, the exact underlying mechanism responsible for these changes is largely unknown and has not yet been studied with magnetic resonance imaging (MRI).
Due to matching, age, waist circumference and blood pressure values were similar between the two groups (age: 60 ± 5 and 59 ± 4 years, p = 0.9, waist circumference: 111 ± 11 vs. 106 ± 9 cm, p = 0.2, systolic blood pressure: 145 ± 17 vs. 142 ± 17 mmHg, p = 0.6, diastolic blood pressure: 88 ± 8 vs. 89 ± 9 mmHg, p = 0.9 resp. in subjects with and without the MS). PWV in the aortic arch and descending aorta was higher in subjects with the MS (7.6 ± 2.2 vs. 5.7 ± 1.1 m/s, p < 0.01 and 7.3 ± 1.9 vs. 6.1 ± 1.1 m/s, p < 0.05). LV diastolic function was diminished in subjects with MS compared to subjects without MS (peak E deceleration:-3.7 ± 1.0 vs. -4.6 ± 1.3 ml/s2, p < 0.05 and mean E deceleration:-2.4 ± 0.7 vs. -3.0 ± 0.9 ml/s2, p < 0.05). PWV in the aortic arch and total aorta (aortic arch and descending aorta) correlated with HDL-cholesterol (resp. r = -0.514, p = 0.003 and r = -0.470, p = 0.007). Furthermore, HDL cholesterol correlated with mean deceleration of the E wave (resp. r = -0.421, p = 0.021). No significant correlation was observed between the other components of the MS and aortic or cardiac function.
Purpose To evaluate the influence of metabolic deregulation on aortic function and LV diastolic function in subjects with the MS using MRI.
Methods MRI was performed in 16 male subjects with the MS and 16 male subjects without the MS who were matched for age, waist circumference and blood pressure. MS was defined using the IDF criteria. Pulse wave velocity (PWV) in the aortic arch and the descending aorta were used as markers for aortic stiffness. Transmitral flow measurements were acquired for evaluation of LV diastolic function. Mean and peak deceleration of the early filling wave (E) were derived. The indepe
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