Evaluation of systo-diastolic cardiac function and arterial stiffness in subjects with new diagnosis of coeliac disease
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Evaluation of systo‑diastolic cardiac function and arterial stiffness in subjects with new diagnosis of coeliac disease without cardiovascular risk factors Edoardo Sciatti1 · Nicola Bernardi1 · Lucia Dallapellegrina1 · Francesca Valentini1 · Davide Fabbricatore1 · Marta Scodro1 · Annunziata Cotugno1 · Marco Alonge2 · Francesca Munari3,4 · Barbara Zanini2 · Chiara Ricci2 · Enrico Vizzardi1 Received: 23 October 2019 / Accepted: 11 December 2019 © Società Italiana di Medicina Interna (SIMI) 2020
Abstract In literature, there are conflicting opinions on the development of cardiovascular disease risk in patients with coeliac disease (CD). The aim of the research was to identify in young subjects without cardiovascular risk factor and newly diagnosed CD, alterations in different instrumental parameters that are associated with an augmented cardiovascular risk. Twenty-one consecutive young adults with a new diagnosis of CD and without cardiovascular risk factors were prospectively enrolled and underwent transthoracic echocardiography to analyse ascending aorta elastic properties [including tissue Doppler imaging strain (TDI-ε)] and left ventricular 2D strains (global longitudinal, radial and circumferential), and applanation tonometry by SphygmoCor. Cases were compared with 21 age- and sex-matched healthy controls. Mean age of the cases was 38 ± 9 years and 15 of them (71%) were female. Brachial and central blood pressure was higher in the CD group. Elastic properties of the ascending aorta were all impaired in the CD group: TDI-ε was altered in 57% of cases (0% of controls, p
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