12.26 Is Brachial Artery Diameter an Early Index of Organ Damage in Hypertension?
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High Blood Press Cardiovasc Prev 2008; 15 (3): 171-215 1120-9879/08/0003-0171/$48.00/0 © 2008 Adis Data Information BV. All rights reserved.
Vessels and Endothelium 12.26 Is Brachial Artery Diameter an Early Index of Organ Damage in Hypertension? G. Pucci, M.R. Mannarino, M. Pirro, J. Helou, G. Vaudo, E. Mannarino, G. Schillaci ` di Perugia, Medicina Interna, Angiologia e Malattie da Arteriosclerosi, Universita Perugia, Italy Introduction. Arteries can enlarge in response to a variety of haemodynamic and non-haemodynamic stimuli. The role of vascular remodelling in atherosclerosis-free arteries in hypertension is poorly understood. Methods. 463 never-treated subjects with uncomplicated essential hypertension (283 men, 180 women; age 48+/-11 years, office blood pressure 155/96+/-17/9 mmHg) underwent M-mode echocardiography, 24-h BP monitoring, and ultrasound assessment of end-diastolic left brachial artery diameter (BAD). 96 healthy normotensive subjects (40% women) served as controls. Analyses were performed separately in men and women. Results. BAD had significant direct associations with age, male sex, systolic blood pressure and body mass index. BAD was larger in hypertensive subjects than in normotensive controls (4.62+/-0.8 vs 4.48+/-0.7 mm, p=0.02). In hypertensive subjects, age-adjusted BAD values were higher in subjects with left ventricular (LV) hypertrophy (LV mass >51 g/m2.7; 4.46+/-0.6 vs 4.04+/-0.6 mm in women, 5.13+/-0.7 vs 4.81+/-0.7 mm in women, both p
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