Bismuth-Based Nanoparticles for CT Imaging
Bismuth (Z = 83) is the heaviest stable nonradioactive element with a strong X-ray attenuation power. On the other hand, bismuth compounds are considered to be nontoxic compared to those of its heavy metal neighbors such as Hg, Tl, and Pb. Despite the ven
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gn and Applications of Nanoparticles in Biomedical Imaging
Design and Applications of Nanoparticles in Biomedical Imaging
Jeff W.M. Bulte • Michel M.J. Modo Editors
Design and Applications of Nanoparticles in Biomedical Imaging
Editors Jeff W.M. Bulte Russell H. Morgan Department of Radiology and Radiological Science The Johns Hopkins University School of Medicine Baltimore, MD, USA
Michel M.J. Modo Department of Radiology University of Pittsburgh Pittsburgh, PA, USA
ISBN 978-3-319-42167-4 ISBN 978-3-319-42169-8 DOI 10.1007/978-3-319-42169-8
(eBook)
Library of Congress Control Number: 2016948724 © Springer International Publishing Switzerland 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Nanoparticles have emerged as an exciting technology platform that can be exploited for diagnostic, therapeutic, and their combined theranostic applications. Their varied chemical compositions can be exploited for use with different imaging modalities, such as magnetic resonance imaging (MRI), magnetic particle imaging (MPI), computer tomography (CT), positron emission tomography (PET) and single-photon emission computed tomography (SPECT), ultrasound (US), as well as optical (fluorescent) imaging. The key determinants for successful use of nanoparticles are sensitivity, specificity, pharmacokinetics, and safety. In the 21 chapters of this book, world-leading experts describe the chemistry, imaging acquisition and processing, as well as the requirements for clinical translation. Applications range from cell tracking in regenerative medicine to the early detection of cancer and inflammation across all major imaging modalities. We hope that this book will provide a fundamental basis for further innovation and synergy of the fields of nanomedicine timely and
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