6.9 Plasma Aldosterone and Albumin Urinary Excretion in Hypertension

  • PDF / 44,507 Bytes
  • 1 Pages / 592.441 x 751.181 pts Page_size
  • 95 Downloads / 198 Views

DOWNLOAD

REPORT


High Blood Press Cardiovasc Prev 2008; 15 (3): 171-215 1120-9879/08/0003-0171/$48.00/0 © 2008 Adis Data Information BV. All rights reserved.

Hormonal Mechanisms 6.9 Plasma Aldosterone and Albumin Urinary Excretion in Hypertension G.L. Colussi (1), C. Catena (1), A. Chiuch (1), E. Nadalini (1), A. Di Fabio (1), L. Sechi (1) ` di Udine, (1)Clinica Medica e Cattedra di Medicina Interna, Universita Udine, Italy Introduction. Preclinical studies indicate that exposure to increased aldosterone levels might result in renal damage but the clinical evidence supporting this role of aldosterone is preliminary. Recent evidence indicates that aldosterone-related renal damage might in part reflect functional and potentially reversible abnormalities initiated by glomerular hyperfiltration. Methods. In this study we examined the relationship between plasma aldosterone (ALDO) and urinary albumin excretion inpatients with hypertension. We analyzed data of 222 grade 1-2 hypertensive patients (age: 49±12; 116 M, 106 F) who were consecutively referred to our unit. Secondary causes of hypertension were excluded after extensive diagnostic work-up that was performed after appropriate drug washout. Anthropometric indices and measurements of plasma lipids, uric acid, glucose, insulin, and HOMA-index were obtained after an overnight fast. Renal function was assessed by 24-h creatinine clearance and urinary albumin excretion, and the albumin-to-creatinine ratio (ACR) was calculated. Plasma active renin and ALDO were measured according to current guidelines and values were referred to the urinary Na excretion. Results. When patients were subdivided according to the median value of ACR (8.6 m g/g) patients with higher values were found to have significantly greater BP, ALDO, insulin, and uric acid levels and HOMA. ACR was directly correlated with mean BP (P