A biodegradable core-sheath nanofibrous 3D hierarchy prepared by emulsion electrospinning for sustained drug release
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A biodegradable core-sheath nanofibrous 3D hierarchy prepared by emulsion electrospinning for sustained drug release Mengzhu Liu1, Xueyan Hao1, Yongpeng Wang1,*
1 2
, Zhenhua Jiang2, and Haibo Zhang2
College of Materials Science and Engineering, Jilin Institute of Chemical Technology, Jilin 132022, China National and Local Joint Engineering Laboratory for Synthesis Technology of High Performance Polymer, Jilin University, Changchun 130012, China
Received: 2 July 2020
ABSTRACT
Accepted: 30 August 2020
A sustained release system that composed of biodegradable core-sheath nanofibers in 3D hierarchy has been developed through electrospinning of water-inoil precursor emulsion, in which theophylline dissolved in water was labeled as ‘aqueous phase’ and PLA solution was considered as ‘organic phase’. SEM images revealed that the fibers crossed and overlapped with each other, forming a 3D network-like structure. TEM indicated that the drug was well incorporated into PLA nanofibers, forming a core-sheath structure, which represented a reservoir-type delivery system. The fiber scaffolds were further characterized by FTIR, XRD, TGA, and DSC, which proved theophylline was successfully loaded into the fibers in an amorphous form. The release of drug consisted of three sequential stages, in which the release rate decreased successively. The changes on release rate were proved to be related to the drug diffusion and polymer degradation. At nearly 30 days, the drug still released continuously. This was accomplished by the gradually swelling and degradation of PLA. The successful preparation of the 3D core-sheath nanofibers can incorporate a water-soluble drug in a biodegradable polymer, which effectively protected the activity of the drug, inhibited a sudden release and accomplished sustained release.
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Springer Science+Business
Media, LLC, part of Springer Nature 2020
Handling Editor: Maude Jimenez.
Address correspondence to E-mail: [email protected]
https://doi.org/10.1007/s10853-020-05205-1
J Mater Sci
GRAPHIC ABSTRACT
Introduction In recent years, the study of drugs release from polymeric devices has attracted considerable attention. Drug release system contains three types: delayed release system, controlled release system and sustained release system [1]. For the first one, it may be not sustaining. The drug in the dosage maintains for some time before release. For the second one, drug is automatically released at a fixed rate within a predetermined period to maintain a constant effective concentration in blood. For the third one, a therapeutic concentration of the drug in the blood is maintained throughout the dosing interval. The latter two types are often merged into controlled release/sustained release system because they have much in common. In these types, more and more researchers are keener on controlled release/sustained release system for it is an ideal drug dosage form especially for chronic diseases. Generally, oral drug delivery is the most convenient and recipient dosage route. In the oral dosage
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