A Heterometallic MOF for Highly Selective Al 3+ Ion Detection and Protective Effect Against Periodontitis by Reducing P.
- PDF / 3,624,878 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 113 Downloads / 182 Views
(0123456789().,-volV)(0123456789().,-volV)
ORIGINAL PAPER
A Heterometallic MOF for Highly Selective Al3+ Ion Detection and Protective Effect Against Periodontitis by Reducing P. gingivalis CFU and Inflammatory Cytokines Levels Yu-Yi Hou1 • Li-Bo Zhou1 • Cun-Fang Meng1 • Jian Guan1 • Guo-Liang Zhang1 • Yu-Ze Hou1 Received: 28 October 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract By employment of an amide-functionalized tetracarboxylic ligand 5,50 -(carbonylbis(azanediyl))-diisophthalic acid (H4cbab), a new polyhedral metal–organic framework (MOF) with the chemical formula of {[InZn2(cbda)2(H2O)2](NMF)3}n (1, NMF = N-methylformamide) has been synthesized under the solvothermal reaction condition. The structural feature was studied via the single crystal X-ray diffraction along with ultimate analysis. This as-prepared MOF shows excellent luminescence performance which can be able to detect Al3? ions selectively. In aqueous solutions, the detection limitation for Al3? ion is 0.56 lM, which is significantly below the highest standard of 7.41 lM for Al3? ion in drinking water that is defined by the World Health Organization (WHO). The protective effect of compound against periodontitis was further explored. The viable cell counts (CFU) number was counted to evaluate the inhibitory effect of compound on bacterial growth. The enzyme linked immunosorbent assay (ELISA) was carried on in order to measure accurately the proportion of inflammatory cytokines in gingival fluid around the implant. The potential binding modes of the synthesized compounds as well as the targeted protein was explored by calculating docking with high accuracy as well as pose scoring process. Keywords MOF Heterometallic framework Al3? ion detection Periodontitis Molecular docking
Introduction Defined as pathologic loss of the periodontal ligament and alveolar bone, and characterized by the destruction of support tissues, the periodontitis is known as a complex, multifactorial, disease, which seriously endanger the human oral health [1, 2]. The periodontitis disease involves complicated dynamic interactions between the particular bacterial pathogens and host immune reaction. Recent reports show that there are more than 700 types of bacteria in the subgingival plaque, and P. gingivalis, an anaerobic bacterium, is one of the major pathogens account for the development of periodontitis [3, 4]. The P. gingivalis infection may induce immunosuppression of cell host and overgrowth of the dangerous bacteria, and potentially
& Yu-Ze Hou [email protected] 1
Department of Stomatology, Jiamusi University, Jiamusi 154002, China
convert periodontitis or stable periodontitis to progressive disease, therefore, using antimicrobial therapy strategy is important for the success of healing and the prevention of periodontitis conditions [5]. Aluminium is a ubiquitous metal in the environment where we live, and its cation plays an important role in our body as well as other biological organism and tissues [6]. However, Al
Data Loading...
