A NEW THREE-DIMENSIONAL Co(II)-MIXED-LIGAND MOF: A PROTECTIVE EFFECT AGAINST ACUTE CEREBRAL INFARCTION BY REDUCING THE H
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A NEW THREE-DIMENSIONAL Co(II)-MIXED-LIGAND MOF: A PROTECTIVE EFFECT AGAINST ACUTE CEREBRAL INFARCTION BY REDUCING THE HS-CRP CONTENT AND INFLAMMATORY RESPONSE J. Xu1, P. Li1, B. He1, H. Gu1, J. Zhuang1*, and H. Peng1**
A novel Co(II)-based metal-organic framework (MOF) {[Co2(TCPP)(BPY)](DMF)3}n (1) with a pillared structure based on 2,3,5,6-tetrakis(4-carboxyphenyl)pyrazine (H4TCPP) and 4,4′-bipyridine (BPY) is designed and synthesized via the solvothermal reaction. Furthermore, a green-hand grinding technique is implemented to reduce the particle size of complex 1 to generate nanoscale 1 (denoted as nano-1 hereafter). After the construction of the acute cerebral infarction animal model, the infarct area of the brain is measured after 2 weeks of treatment with the compound. Then, ELISA is performed to detect the content of hs-CRP and IL-1β and TNF-α in the serum. DOI: 10.1134/S0022476620070173 Keywords: Co(II)-complex, metal-organic framework, nanoscale compound, acute cerebral infarction.
INTRODUCTION Acute cerebral infarction refers to the localized ischemic necrosis or brain softening induced by the disorder of brain blood supply, ischemic and hypoxic [1]. The incidence, mortality, morbidity, complication and recurrence rates of acute cerebral infarction in middle-aged and elderly people in China is increasing ever year [2]. The high-sensitivity C-reactive protein (hs-CRP) is a non-specific, acute phase protein synthesized by hepatocytes after injury. It is involved in the nonspecific inflammatory response during the development of acute cerebral infarction, which has been proven to play an important predictive role for the development of acute cerebral infarction [3, 4]. Metal-organic frameworks (MOFs) are hybrid crystalline materials featuring metal-based nodes connected by organic linkers [5-7]. Their high tunability coupled by unrivaled porosity has led to their proof-of-concept use in applications such as gas storage and separation, catalysis, sensing, and light harvesting [8-10]. One particularly promising and extensively studied class of MOFs are pillared-paddlewheel materials composed of two-dimensional (2D) sheets featuring binuclear metal centers linked by carboxylate-based ligands. They can be assembled into three-dimensional (3D) structures through pillaring with a ditopic nitrogen donor linker [11]. As mixed-linker MOFs, these materials offer ample opportunities for incorporating functional group. Moreover, an extension of the nitrogen donor pillar can potentially yield MOFs with ultralarge cavities, great porosity, and good framework stability. For instance, the Tan and Liang group synthesized
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Department of Neurology, Chang Zheng Hospital, Navy Medical University, Shanghai, P. R. China; *[email protected]; **[email protected]. Original article submitted September 10, 2019; revised September 29, 2019; accepted September 30, 2019. 1132
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a sequence of isostructural M2(bdc)2(dabco) materials with pillared-paddlewheel structures and e
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