A missense polymorphism (rs11466653, Met326Thr) of toll-like receptor 10 ( TLR10 ) is associated with tumor size of papi
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ORIGINAL ARTICLE
A missense polymorphism (rs11466653, Met326Thr) of toll-like receptor 10 (TLR10) is associated with tumor size of papillary thyroid carcinoma in the Korean population Su Kang Kim • Hae Jeong Park • Il Ki Hong Joo-Ho Chung • Young Gyu Eun
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Received: 16 May 2012 / Accepted: 23 August 2012 / Published online: 3 November 2012 Ó Springer Science+Business Media, LLC 2012
Abstract Toll-like receptors (TLRs) are important components of innate immune response. The aim of this study was to investigate whether TLR gene cluster (TLR10TLR1-TLR6) polymorphisms are associated with the etiology of papillary thyroid carcinoma (PTC) and its clinicopathologic characteristics. We recruited 94 PTC patients and 325 control subjects. Genotypes for each SNP were determined by direct sequencing. SNPStats and SPSS 18.0 were used to evaluate odds ratios (ORs), 95 % confidence intervals (CIs), and P values. Multiple logistic regression analyzes of genetic data were performed. The missense SNP rs11466653 was associated with small tumor size (\1 cm) in PTC. The frequency of the rs11466653 T allele was higher in PTC patients with tumors \1 cm in size than in the control group (95.8 vs. 87.2 %; P = 0.021, OR = 0.30, 95 % CI = 0.11–0.83). The T allele of rs11466653 (T/C, Met326Thr) in TLR10 may be a risk factor for the development of tumors in PTC in the Korean population.
Joo-Ho Chung and Young Gyu Eun contributed equally to this study. S. K. Kim H. J. Park J.-H. Chung (&) Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 130-701, Korea e-mail: [email protected] I. K. Hong Nuclear Medicine, School of Medicine, Kyung Hee University, Seoul 130-702, Korea Y. G. Eun (&) Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul 130-702, Korea e-mail: [email protected]
Keywords Toll-like receptor Papillary thyroid carcinoma Single nucleotide polymorphism Tumor size Association study
Introduction Papillary thyroid carcinoma (PTC), which develops in the follicular cells of the thyroid, is the most common type of thyroid cancer. The incidence of PTC has rapidly increased around the world during the past 10–20 years, probably because the detection of small, low-risk PTC has become more common. According to data from the National Cancer Center of Korea (http://www.cancer.go.kr), thyroid cancer is the most common cancer among Korean adolescents and adults between ages 15 and 34 years [1], and most cases are PTC. Most PTC patients who undergo thyroidectomy following thyroid hormone suppression and radioactive iodine ablation treatments have good prognoses. However, PTC recurs in some patients and is the major cause of endocrine cancer death [2, 3]. It is not clear what causes thyroid cancer. In general, doctors have suggested that risk factors are associated with thyroid cancer such as radiation, family history, or not enough iodine in the diet. These three factors are recognized as risk factors. However, these risk factors may or may not incurred th
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