A New Cyclo-Oxygenase-2 Gene Variant in the Han Chinese Population is Associated with an Increased Risk of Gastric Carci
- PDF / 136,352 Bytes
- 5 Pages / 612.28 x 790.87 pts Page_size
- 31 Downloads / 188 Views
Mol Diagn Ther 2010; 14 (6): 351-355 1177-1062/10/0006-0351/$49.95/0
ยช 2010 Adis Data Information BV. All rights reserved.
A New Cyclo-Oxygenase-2 Gene Variant in the Han Chinese Population is Associated with an Increased Risk of Gastric Carcinoma Yumin Li,1,2 Wenting He,2,3 Tao Liu1,2 and Quanbao Zhang3 1 Second Hospital of Lanzhou University, Lanzhou, Gansu, China 2 Key Laboratory of Digestive System, Lanzhou, Gansu, China 3 First Hospital of Lanzhou University, Lanzhou, Gansu, China
Abstract
Background and Objective: Cyclo-oxygenase-2 (COX-2, also known as prostaglandin synthase 2) influences carcinogenesis through regulation of angiogenesis, apoptosis, and cytokine expression. COX-2 is encoded by the gene PTGS2. Several studies have suggested that PTGS2 single-nucleotide polymorphisms (SNPs) are involved in gastrointestinal carcinogenesis. In this study, we observed the PTGS2 Val511Ala (5939T/C) polymorphism in the Chinese population for the first time, and investigated whether this polymorphism might contribute to gastric cancer in a case-control study conducted in the Gansu province of China, a highrisk area for gastric cancer. Methods: We determined the genotypes of 110 gastric cancer patients and 138 controls using polymerase chain reaction (PCR)-based restriction fragment length polymorphism (RFLP) analysis. Data were statistically analyzed using a chi-squared test and a logistic regression model. Results and Conclusion: In our analysis, PTGS2 5939C allele carriers were at increased risk of gastric cancer (odds ratio [OR] 1.742; 95% confidence interval [CI] 1.009, 3.005; p = 0.045). We also found an interaction between Helicobacter pylori infection, a family history of gastric cancer, and presence of the 5939C allele. This study further indicated that H. pylori-positive status and family history jointly contribute to a higher risk of gastric cancer.
Introduction Gastric cancer is a very common disease worldwide and the second most frequent cause of cancer death, affecting about one million people per year.[1] Genetic traits of affected individuals and a wide range of risk factors have classified it as a complex disease.[2] There is evidence that single nucleotide polymorphisms (SNPs) of some genes are closely associated with gastric carcinogenesis,[3] and our previous studies have shown that the homozygosity for the 762Ala allele of the poly(ADPribose) polymerase-1 (PARP1) Val762Ala polymorphism is a significant risk factor for gastric cancer.[4] Cyclo-oxygenase-2 (COX-2; prostaglandin synthase 2), a rate-limiting enzyme that catalyzes the formation of prostaglandins from arachidonic acid, plays an important role in the progression of gastric cancer.[5] We have found that COX-2
inhibitors are valuable for gastric cancer therapy.[6] Several studies have suggested that SNPs in the COX-2 gene PTGS2 are involved in gastrointestinal carcinogenesis.[7] A case-control study performed in a Dutch population showed that the G allele of the PTGS2 -765G/C promoter polymorphism is significantly associated with ga
Data Loading...
