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ORIGINAL ARTICLE

A reduced liver 18F‑FDG uptake may be related to hypoalbuminemia in patients with malnutrition Yoichi Otomi1 · Hideki Otsuka1   · Kaori Terazawa1 · Mihoko Kondo1 · Yuta Arai1 · Moriaki Yamanaka1 · Maki Otomo1 · Takashi Abe1 · Takayoshi Shinya1 · Masafumi Harada1 Received: 12 March 2019 / Accepted: 9 June 2019 © The Japanese Society of Nuclear Medicine 2019

Abstract Objective  18F-FDG PET/CT is a hybrid imaging method widely used as a useful, noninvasive imaging modality for evaluating various neoplastic diseases. When assessing the tumor uptake, the liver and the mediastinal blood pool are often used as a reference region. In daily clinical practice, the 18F-FDG uptake in the liver sometimes appears to decrease on PET images of patients with malnutrition. The purpose of this study was to investigate whether or not the liver 18F-FDG uptake is decreased in patients with malnutrition. Methods  We retrospectively analyzed 246 patients who underwent 18F-FDG PET/CT from January 2018 to June 2018 and whose blood serum albumin was measured within 1 month of PET/CT. We compared the liver uptake and mediastinal blood uptake of patients with low serum albumin level (

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