Abnormal rich club organization in end-stage renal disease patients before dialysis initiation and undergoing maintenanc
- PDF / 1,634,967 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 65 Downloads / 174 Views
RESEARCH ARTICLE
Open Access
Abnormal rich club organization in endstage renal disease patients before dialysis initiation and undergoing maintenance hemodialysis Shaohui Ma1, Ming Zhang1, Yang Liu2,3, Dun Ding4, Peng Li1,5, Xueying Ma6, Hongjuan Liu1* and Junya Mu2,3,7*
Abstract Background: End-stage renal disease (ESRD) patients are at a substantially higher risk for developing cognitive impairment compared with the healthy population. Dialysis is an essential way to maintain the life of ESRD patients. Based on previous research, there isn’t an uncontested result whether cognition was improved or worsened during dialysis. Methods: To explore the impact of dialysis treatment on cognitive performance, we recruited healthy controls (HCs), predialysis ESRD patients (predialysis group), and maintenance hemodialysis ESRD patients (HD group). All ESRD patients performed six blood biochemistry tests (hemoglobin, urea, cystatin C, Na+, K+, and parathyroid hormone). Neuropsychological tests were used to measure cognitive function. By using diffusion tensor imaging and graph-theory approaches, the topological organization of the whole-brain structural network was investigated. Generalized linear models (GLMs) were performed to investigate blood biochemistry predictors of the neuropsychological tests and the results of graph analyses in the HD group and predialysis group. Results: Neuropsychological analysis showed the HD group exhibited better cognitive function than the predialysis group, but both were worse than HCs. Whole-brain graph analyses revealed that increased global efficiency and normalized shortest path length remained in the predialysis group and HD group than the HCs. Besides, a lower normalized clustering coefficient was found in the predialysis group relative to the HCs and HD group. For the GLM analysis, only the Cystatin C level was significantly associated with the average fiber length of rich club connections in the predialysis group. Conclusions: Our study revealed that dialysis had a limited effect on cognitive improvement. Keywords: End-stage renal disease, Dialysis initiation, Graph analyses, Cystatin C
* Correspondence: [email protected]; [email protected] 1 Department of Medical Imaging, First Affiliated Hospital of Xi’an Jiaotong University, No. 277, West Yanta Road, Xi’an 710061, Shaanxi-Province, People’s Republic of China 2 Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi’an 710126, People’s Republic of China Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commo
Data Loading...
