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ABSTRACTS
Abstracts 32nd Congress of the ESP and XXXIII International Congress of the IAP
Oral Free Paper Sessions OFP-01 Joint Oral Free Paper Session: Uropathology / Nephropathology
OFP-01-001 Kidney biopsy codes for pathologists-mapping to SNOMED CT A. Dendooven*, M.J. Helbert, H. Peetermans, S. Leh *UZ Gent, Universiteit Antwerpen, Belgium Background & objectives: The “Kidney Biopsy Codes (KBC)” project provides terms that allow any diagnosis and/or histomorphological pattern for a non-neoplastic kidney biopsy to be coded. We explored whether mapping to SNOMED CT is feasible, to enable aggregation and computerized exchange of data. Methods: For KBC terms for which an unambiguous match with a preexisting SNOMED CT concept was available, both ‘parent concept’ and the place in the SNOMED taxonomy were established. For remaining terms, we explored whether these could be defined by combining preexisting (more simple) SNOMED CT concepts. This process ('post-coordination’) is well supported by SNOMED CT and allows extending its content. Results: Of glomerular terms, 88/195 (45%) could be matched to SNOMED CT. %-matching was more successful for KBC terms designating disease concepts (56%) than patterns of injury (32%). For the majority of terms that could not be mapped, we found that these could indeed be defined as a compositional expression of pre-existing SNOMED CT concepts (post-coordination). We suggested concepts that are needed for this post-coordination. Conclusion: SNOMED CT is considered the standard for documenting, encoding and exchanging medical data in/between health information systems. This proof-of-concept shows that mapping of KBC terms to SNOMED CT is feasible, in part directly, in part through post-coordination. OFP-01-002 Molecular analysis of renal transplant biopsies comparing the Edmonton Molecular Microscope with the NanoString Human Organ Transplant Panel J. Schmitz*, H. Stark, S. Bartels, D. Jonigk, P.F. Halloran, G. Einecke, J.H. Bräsen *Institute of Pathology, Nephropathology Unit, Hannover Medical School, Germany Background & objectives: Different molecular methods like microarrays or quantitative PCRs were used by several groups on renal transplant tissues. High-resolution determination of the inflammatory infiltrate by NanoString analysis (which was developed for formalin-fixed paraffinembedded-derived RNA) should be a sufficient approach. Methods: We used surveillance and indication biopsies from 63 patients whose time-matched second biopsy core had been frozen and analysed by microarray in the INTERCOM/INTERCOMEX study. After reevaluation according to recent Banff consensus, RNA isolation was performed with Maxwell FFPE kits and led to sufficient RNA yields in 53
samples which were further processed for NanoString analysis (Human Organ Transplant panel). Results: Morphologically, of the 53 samples analysed (samples from 2011/12 and 2015), twenty-five patients showed no signs of rejection, twelve had borderline rejection, four showed cellular rejection, seven had humoral rejection,
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