Abstracts
- PDF / 8,401,015 Bytes
- 436 Pages / 595.276 x 790.866 pts Page_size
- 117 Downloads / 197 Views
ABSTRACTS
Abstracts 31st European Congress of Pathology
Oral Free Paper Sessions Sunday, 8 September 2019, 08:30 - 12:00, Galliéni 5 OFP-01 | Joint Session: Uropathology / Nephropathology
OFP-01-001 The influence of the presence of intraductal carcinoma of the prostate on the grade group system's prognostic performance T. Tsuzuki1, M. Kato2 1 Department of Surgical Pathology, Aichi Medical University Hospital, Japan, 2 Department of Urology, Nagoya University Graduate School of Medicine, Japan Background & Objectives: Although the presence of intraductal carcinoma of the prostate (IDC-P) influences biochemical failure in radical prostatectomy patients, no data are available regarding the impact of its integration into the classification Grade Group system. Thus, the aim of this study was to enhance the utility of the Grade Group (GG) system by integrating the presence of IDC-P. Methods: This study was a retrospective evaluation of 1019 patients with prostate cancer who underwent radical prostatectomy between 2005 and 2013 without neoadjuvant or adjuvant therapy. Data on age, prostatespecific antigen (PSA) level at diagnosis, pathological T stage (pT), the presence of Gleason pattern 5 (GP5), the presence of IDC-P, and surgical margin status were analysed to predict PSA recurrence after prostatectomy. Results: IDC-P was detected in 157 patients (15.4%). GGs were as follows: GG1 without IDC-P, n=163; GG2 without IDC-P, n=470; GG3 without IDC-P, n=160; GG4 without IDC-P, n=27; GG5 without IDC-P, n=42; any GG with IDC-P, [n=157; GG 2 (n=29); GG3 (n=60); GG4 (n=13); GG5 (n=55)]. Any GG with IDC-P showed a significantly worse prognosis than any other GG without IDC-P (p< 0.0001). In a multivariate analysis, integration of the IDC-P into the GGs was significant prognostic predictors (P < 0.0001). Conclusion: Integrating the presence of IDC-P into the GG system will result in more accurate predictions of patient outcome.
OFP-01-002 Distinct genetic alterations and luminal molecular subtype in nested variant of urothelial carcinoma V. Weyerer1, R. Weisser1, E.A. Moskalev1, F. Haller1, R. Stoehr1, M. Eckstein1, U. Zinnall2, N.T. Gaisa3, E. Compèrat4, A. Perren5, B. Keck6, Y. Allory7, G. Kristiansen8, B. Wullich6, A. Agaimy1, A. Hartmann1, S. Bertz1 1 Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen, Germany, 2 Institute of Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association,
Berlin, Germany, 3 Institute of Pathology, RWTH Aachen University, Germany, 4 Hôpital Tenon, HUEP, Sorbonne University, Paris, France, 5 Institute of Pathology, University of Bern, Switzerland, 6 Department of Urology and Paediatric Urology, University Hospital Erlangen, FriedrichAlexander Universität Erlangen-Nuernberg, Germany, 7 Department of Pathology, Hôpital Foch, Universitè Versailles-Saint-Quentin-en-Yvelines, Universitè Paris-Saclay, Suresnes, Francle; Institut Curie, CNRS, UMR144, Paris, France, 8 Institute of Pathology, University Hospital Bonn, Germ
Data Loading...
