Aciclovir
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Acute kidney injury: case report A 17-year-old girl developed acute kidney injury during treatment with aciclovir for viral meningitis [duration of treatment to reaction onset stated]. The girl presented with a 4 days history of nausea, severe headache, and admitted to a hospital in Poland on 08 August 2017. Following various examination, she was diagnosed with viral meningitis and PCR testing was positive for varicella-zoster virus. Hence, treatment with IV aciclovir [Acix; dosage not stated]. On the same day, she also experienced hypoacusis and pain of the left ear along with left facial palsy that lead to a diagnosis of Ramsay hunt syndrome (RHS). Treatment with dexamethasone was initiated and her symptoms improved. Eventually, she was discharged with prednisone. Two days later, she again presented to the hospital with vomiting and severe vertigo. Her findings were consistent with dysfunction of cranial nerve VIII with concurrent RHS. Dexamethasone and IV aciclovir were readministered and some improvement was observed. However, after 3 days, she developed acute kidney injury secondary to aciclovir and her creatinine level was elevated. Hence, the girl’s treatment with aciclovir was discontinued. She also received amlodipine for hypertension. Within 3 days, kidney function normalised. Thereafter, her RHS and dysfunction of cranial nerve improved. She was discharged after 17 days and on follow-up after a month, she was recovered completely. Bienkowski C, et al. Meningitis and Ramsay-Hunt syndrome in a 17-year old girl. Neuro Endocrinology Letters 40: 149-151, No. 3, 10 Sep 2019. Available from: URL: 803498058 https://pubmed.ncbi.nlm.nih.gov/31816219/
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Reactions 29 Aug 2020 No. 1819
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