Aciclovir
- PDF / 151,736 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 49 Downloads / 132 Views
1 S
Aciclovir Various toxicities: case report
A 53-year-old man developed severe polyuric syndrome, symptomatic orthostatic hypotensive episodes and hypovolemic profile secondary to proximal tubulopathy following treatment with aciclovir for Varicella-zoster virus (VZV) infection. This case has been declared to Regional Center of Pharmaovigilance of Angers on 13th January 2017 (reference number AN20170059). The man, who had Hodgkin lymphoma and acute myeloid leukaemia, underwent allogenic haematopoietic stem cells transplantation in 2014. Thereafter, he developed chronic graft versus host disease. Therefore, he started receiving ruxolitinib. Six months later, he was admitted to the ICU with severe hypoxaemic VZV pneumonia and respiratory failure. VZV infection was confirmed. He started receiving IV aciclovir [acyclovir] 10 mg/kg three times a day. His past medication consisted of piperacillin/ tazobactam and unspecified steroids. Following initiation of aciclovir, his respiratory failure improved. At day 7, his oxygen therapy was withdrawn and he was discharged from the ICU. Two days after the discharge, he suddenly developed a severe polyuric syndrome. The polyuria was associated with symptomatic orthostatic hypotensive episodes. Haemodynamic monitoring with central venous pressure and echocardiography revealed a hypovolaemic profile. Laboratory investigation revealed hypophosphataemia, hypokalaemia, hypouricaemia and severe salt loss. The man was treated with sodium chloride. His kidney function remained in normal range. Based on investigational findings, drug-induced tubulopathy was highly suspected. Therefore, aciclovir and ruxolitinib were discontinued. Due to the severity of polyuria and need for close monitoring of inputs and outputs, he was re-admitted to the ICU. He was treated with sodium chloride, sodium and potassium. After 28 days, his condition progressively improved. He was discharged from the ICU on day 30. After excluding other causes, a final diagnosis of aciclovir-induced proximal tubulopathy was considered. Yvin E, et al. Severe polyuria secondary to acyclovir induced-proximal tubulopathy. Therapies : 2020. Available from: URL: http://doi.org/10.1016/ j.therap.2020.08.001
0114-9954/20/1826-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
803508243
Reactions 17 Oct 2020 No. 1826
Data Loading...
