Acute Endocrinology From Cause to Consequence

The integration of endocrinology in critical care medicine has led to new experimental and clinical data on the complex endocrine and metabolic derangements accompanying non-endocrine severe illnesses. The joining of these two disciplines has generated im

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A CUTE E NDOCRINOLOGY F ROM C AUSE TO C ONSEQUENCE Edited by

G REET V AN MD , P h D

DEN

B ERGHE ,

Catholic University of Leuven, Department of Intensive Care Medicine, Leuven, Belgium

Greet Van den Berghe Catholic University of Leuven Department of Intensive Care Medicine, Leuven Belgium [email protected]

ISBN: 978-1-60327-176-9 DOI: 10.1007/978-1-60327-177-6

e-ISBN: 978-1-60327-177-6

Library of Congress Control Number: 2008933363 c 2008 Humana Press, a part of Springer Science+Business Media, LLC  All rights reserved. This work may not be translated or copied in whole or in part without the wiritten permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper springer.com

Preface Until recently, endocrinology and critical care medicine were two specialties in medicine that were rather uncomfortable with each other and hence quite isolated. Fortunately, these two ‘alien’ disciplines have joined forces in successful attempts to perform high quality research in order to clarify the unknown. By integrating endocrinology in critical care medicine, or vice-versa depending on the specialty of the observer, new experimental and clinical data on the complex endocrine and metabolic derangements accompanying non-endocrine severe illnesses came available which generated important novel insights with relevant clinical implications. In addition, the state of the art diagnosis and management of primary endocrine diseases that represent life-threatening situations leading to ICU admission has been updated. This issue of Contemporary Endocrinology aims at compiling the new findings. The book indeed covers both areas of ‘Acute Endocrinology’ that are often taking care of at very distant sites within hospitals. The first part deals with the classical life-threatening illnesses caused by primary endocrine diseases such as thyrotoxicosis, hypothyroidism, acute adrenal crisis, acute calcium disorders, pheochromocytoma, severe hyper- and hypoglycemia . The second part looks at endocrinology from the ICU side, starting with a general overview of the dynamic neuroendocrine and metabolic stress responses in the condition of intensive care-dependent, non-endocrine critical illness. Alterations within several of the endocrine axes briefly touched upon in the overview chapter are then further discussed in detail in the following chapters