Acute Toxicity and Risk Assessment of Florfenicol for Nile Tilapia Larvae
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Acute Toxicity and Risk Assessment of Florfenicol for Nile Tilapia Larvae Cristiano Campos Mattioli1 · Bruna Milke Chiste1 · Natalia Akemi Takeshita1 · Claudio Martin Jonsson1 · Vera Lucia Ferracini1 · Hamilton Hisano1 Received: 16 June 2020 / Accepted: 28 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract The aim of this study was to determine the median lethal concentration ( LC50−96h), effective concentration ( EC50−96h), risk assessment, and development of Nile tilapia Oreochromis niloticus larvae submitted to florfenicol (FF) exposure. Fish (n = 147; 8.6 ± 0.6 mg; 7 fish/aquarium) were randomly distributed in 21 aquaria (1 L) and exposed to five concentrations of FF 58.73; 131.31; 198.96; 241.88 and 381.81 mg L−1 plus one control and a control with solvent, totalizing seven treatments and three replicates. The estimated median L C50−96h of FF for Nile tilapia larvae was 349.94 mg L−1. The E C50−96h of −1 FF was 500 mg L for weight reduction and was 1040 mg L−1 for length reduction. After the exposure period, final weight and length differed (p
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