Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors
Open image in new window Adhesion GPCRs as mechanosensors. Different aGPCR homologs and their cognate ligands have been described in settings, which suggest that they function in a mechanosensory capacity. For details, see text
- PDF / 992,494 Bytes
- 27 Pages / 439.37 x 666.142 pts Page_size
- 54 Downloads / 156 Views
Graphical Abstract
Force
Force
Force
Force
Adhesion GPCRs as mechanosensors. Different aGPCR homologs and their cognate ligands have been described in settings, which suggest that they function in a mechanosensory capacity. For details, see text N. Scholz (*) • R.J. Kittel • T. Langenhan (*) Department of Neurophysiology, Institute of Physiology, University of W€ urzburg, R€ ontgenring 9, W€ urzburg 97070, Germany e-mail: [email protected]; [email protected] K.R. Monk Department of Developmental Biology, Hope Center for Neurologic Disorders, Washington University School of Medicine, St. Louis 63110, MO, USA
# Springer International Publishing AG 2016 T. Langenhan, T. Scho¨neberg (eds.), Adhesion G Protein-coupled Receptors, Handbook of Experimental Pharmacology 234, DOI 10.1007/978-3-319-41523-9_10
221
222
N. Scholz et al.
Contents 1 General Overview of Mechanosensation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Established Mechanosensors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.1 Molecular Models of Mechanosensation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.2 IonotropicIonotropic mechanosensor Mechanosensors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.3 Integrins and Cadherins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.4 Metabotropic Mechanosensors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Adhesion GPCRs in Mechanosensation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3.1 GPR126/ADGRG6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3.2 Latrophilins/ADGRL1–ADGRL3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3.3 GPR56/ADGRG1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3.4 Mechanosensation by Other Adhesion GPCRs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
222 223 223 224 227 229 230 234 235 236 237 237 238
Abstract
G protein-coupled receptors (GPCRs) constitute the most versatile superfamily of biosensors. This group of receptors is formed by hundreds of GPCRs, each of which is tuned to the perception of a specific set of stimuli
Data Loading...
