Amlodipine
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Gingival enlargement: case report A 56-year-old man developed gingival enlargement during treatment with amlodipine for hypertension. The man, who had a 3-year history of type 2 diabetes, hypertension, hepatitis C, renal failure and a monoclonal gammopathy of undetermined significance, presented to the hospital with severe gingival enlargement. His medications included amlodipine 10 mg/day since 3 years [route not stated] Long with furosemide, perindopril, insulin and nebivolol. At presentation, an intraoral examination revealed an unusual presentation of gingival enlargement on both buccal and lingual sides, posterior and anterior teeth and mainly on the anterior teeth. The superior canines were extremely mobile and were extracted to reduce the local inflammation. Panoramic radiograph showed a dramatic bone loss and terminal periodontitis. Malignant disorder was ruled out by biopsy. A nonspecific inflammatory overhaul with a predominance of lymphocytes was noted in histological examination. Based on all the findings, amlodipine-induced severe gingival enlargement was suspected, which affected both mandibular and maxillary arches leading to dental malposition [duration of treatment to reaction onset not stated]. The man’s amlodipine therapy was discontinued, after which his symptoms improved gradually over a period of one month. The remaining teeth were mobile, except for the lower canines, and were extracted. His poor oral hygiene also contributed to the teeth loss, and the lost teeth were replaced by a mobile denture. At a 1-year follow-up, no recurrence was noted. Quenel L, et al. Amlodipine-induced gingival enlargement: A case report. Journal of Stomatology, Oral and Maxillofacial Surgery 121: 308-311, No. 3, Jun 2020. Available 803506638 from: URL: http://doi.org/10.1016/j.jormas.2019.04.014
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Reactions 17 Oct 2020 No. 1826
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