An Antigen Depository of the Immune System: Follicular Dendritic Cells
Follicular dendritic cells (FOe) are unique among cells of the immune system. While their morphological characteristics re sulted in their inclusion as a 'dendritic cell type', tt1ey differ quite significantly from the other members of the dendritic cell
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Editors
A. Capron, Lille . R.W. Compans, Atlanta/Georgia M. Cooper, Birmingham/Alabama· H. Koprowski, Philadelphia· I. McConnell, Edinburgh· F. Melchers, Basel M. Oldstone, La Jolla/California· S. Olsnes, Oslo M. Potter, Bethesda/Maryland· H. Saedler, Cologne P.K. Vogt, La Jolla/California· H. Wagner, Munich I. Wilson, La Jolla/California
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An Antigen Depository of the Immune System: Follicular Dendritic Cells Edited by Marie H. Kosco-Vilbois
With 39 Figures
Springer
MARIE
H.
KOSCO-VILBOIS
Glaxo Institute for Immunology 14, Chemin des Aulx 1228 Plan-Ies-Ouates Switzerland
Cover illustration: The cover illustration which combines a background of scanning electron micrographs with two contrasting cartoon overlays, is designed to emphasize the changing morphology of the FDC from filiform to beaded dendrities during its functional relationship with B cells of the developing germinal center. The yellow overlay depicts the mystery of the FDC (blue)-antigen (red)-iccosome (beads)-B cell (maroon) microenvironment. In this unique setting, the FDC transfers the retained antigen via iccosomes to germinal center B cells. The blue overlay shows the B cell endocytosing the iccosomes for antigen-processing. Via the Golgi apparatus and transport vesicles, the processed iccosomal antigens are then re-expressed at the B cell's surface for presentation to T cells. (Professor Andras K. Szakal, Department of Anatomy, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia) Cover design: Kunkel+Lopka, IIvesheim ISSN 0070-217X ISBN-13:978-3-642-79605-0 001: 10.1007/978-3-642-79603-6
e-ISBN-13:978-3-642-79603-6
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© Springer-Verlag Berlin Heidelberg 1995 Library of Congress Catalog Card Number 15-12910 Softcover reprint of the hardcover 1st edition 1995
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