An association was found between maternal fluoxetine use and infantile hypertrophic pylorus stenosis
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■ An association was found between maternal fluoxetine use and infantile hypertrophic pylorus stenosis in a study performed by investigators from The Netherlands, although they state that "we cannot rule out the possibility of chance". Using the database of a population-based birth defects registry, the investigators found that 3 of 178 (1.7%) of infants with hypertrophic pylorus stenosis were exposed to fluoxetine during the first trimester of pregnancy, compared with 8 of 4077 (0.2%) fluoxetine exposures among infants with other malformations (p = 0.009). Additional case-control analyses, using controls with a genetic disorder and adjusting for maternal age and smoking in the first trimester, yielded an OR of 9.8 for the association (95% CI 1.5, 62.0). Bakker MK, et al. Fluoxetine and infantile hypertrophic pylorus stenosis: a signal from a birth defects-drug exposure surveillance study. Pharmacoepidemiology and Drug Safety : 23 Jun 2010. Available from: URL: 803027921 http://dx.doi.org/10.1002/pds.1964
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Reactions 31 Jul 2010 No. 1312
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