Antenatal exposure to fenoterol is not associated with the development of retinopathy of prematurity in infants born bef
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MATERNAL-FETAL MEDICINE
Antenatal exposure to fenoterol is not associated with the development of retinopathy of prematurity in infants born before 32 weeks of gestation Hannes Hudalla1 · Thomas Bruckner2 · Johannes Pöschl1 · Thomas Strowitzki3 · Ruben‑J. Kuon3 Received: 14 November 2019 / Accepted: 13 February 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Despite safety concerns, β2-sympathomimetics are still widely used as tocolytic agents. β-Blockers in turn are used to treat vasculo-proliferative diseases of the newborn such as retinopathy of prematurity (ROP), which may lead to visual impairment and blindness. The scope of this study was to investigate whether antenatal exposure to the β2-sympathomimetic fenoterol contributes to the development of ROP. Methods For this single-center retrospective case–control study of prospectively collected clinical data, all infants born before 32 weeks of gestation between 2001 and 2012 were included. The association of prenatal exposure to fenoterol and the development of ROP were analyzed by multivariate logistic regression. Results n = 1134 infants
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