Anti- Saccharomyces cerevisiae Antibodies are Frequent in Type 1 Diabetes
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Anti-Saccharomyces cerevisiae Antibodies are Frequent in Type 1 Diabetes Wahiba Sakly & Amani Mankaï & Nabil Sakly & Yosra Thabet & Achouak Achour & Leila Ghedira-Besbes & Moncef Jeddi & Ibtissem Ghedira
Published online: 13 April 2010 # Springer Science+Business Media, LLC 2010
Abstract Anti-Saccharomyces cerevisiae antibodies (ASCA) have been described in many autoimmune diseases in which there is an increased intestinal permeability. Also in type 1 diabetes (T1D), there is an increased intestinal permeability. Since no data are available about ASCA in T1D, we evaluated, retrospectively, the frequency of ASCA in this disease. ASCA, IgG, and IgA, were determined by ELISA in sera of 224 T1D patients in which coeliac disease has been excluded and 157 healthy control group. The frequency of ASCA (IgG or IgA) was significantly higher in T1D patients than in the control group (24.5% vs. 2.5%, p
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