Antiepileptic Drugs and Pregnancy A Guide for Prescribers
A description of our current understanding of antiepileptic drug use during pregnancy, this book includes chapters on the impact of seizures on the mother and developing child, changes in maternal physiology during pregnancy and its impact on drug disposi
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Antiepileptic Drugs and Pregnancy A Guide for Prescribers
Antiepileptic Drugs and Pregnancy
MJ Eadie • FJE Vajda
Antiepileptic Drugs and Pregnancy A Guide for Prescribers
Adis
MJ Eadie Emeritus Professor of Clinical Neurology and Neuropharmacology, University of Queensland, and Honorary Consultant Neurologist, Royal Brisbane and Women's Hospital Brisbane, QLD Australia
FJE Vajda Department of Medicine and Neurology Director of the Australian Epilepsy and Pregnancy Register, University of Melbourne and Royal Melbourne Hospital Melbourne Australia
ISBN 978-3-319-21433-7 ISBN 978-3-319-21434-4 DOI 10.1007/978-3-319-21434-4
(eBook)
Library of Congress Control Number: 2015949390 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Adis is a brand of Springer Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www. springer.com)
Preface
A prospective reader might well wonder why, at the present time, anyone would devote a monograph to such a seemingly limited topic as that of antiepileptic drugs and pregnancy. This is particularly so when it is generally accepted that, as far as possible, the use of therapeutic drugs should be avoided in pregnant women. This latter belief originated some half a century ago when thalidomide use in pregnant women was recognised to be responsible for the development of foetal malformations and when the prescription of stilbestrol for threatened miscarriage was found to result in gynaecological malignancies in the daughters of the women so treated. The short answer to the question posed above is that the use of antiepileptic drug therapy in pregnancy continues to be perhaps the most frequently encountered situation in which the use of therapeutic drugs in pregnant women appears clinically and ethically justified. As a result of the virtual embargo on the unnecessary use of
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