Antimicrobial Peptides and Human Disease
Microbes are in our midst soon after birth. Thankfully, the number of harmless (and often beneficial) microbes far outnumber those that would do us harm. Our ability to ward-off pathogens in our environment, including those that can colonize our exterior
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Editors R.W. Compans, Atlanta/Georgia M.D. Cooper, Birmingham/Alabama T. Honjo, Kyoto · H. Koprowski, Philadelphia/Pennsylvania F. Melchers, Basel · M.B.A. Oldstone, La Jolla/California S. Olsnes, Oslo · P.K. Vogt, La Jolla/California H. Wagner, Munich
W.M. Shafer (Ed.)
Antimicrobial Peptides and Human Disease
With 12 Figures and 4 Tables
123
William M. Shafer, Ph.D. Department of Microbiology and Immunology 3001 Rollins Research Center Emory University School of Medicine Atlanta, GA 30322 USA e-mail: [email protected] Cover Illustration by Dawn M.E. Bowdish, Donald J. Davidson and Robert E.W. Hancock (Cover figure reproduced with kind permission of Leukemia Research) (this volume)
Library of Congress Catalog Number 72-152360 ISSN 0070-217X ISBN-10 3-540-29915-7 Springer Berlin Heidelberg New York ISBN-13 978-3-540-29915-8 Springer Berlin Heidelberg New York This work is subject to copyright. All rights reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September, 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springeronline.com © Springer-Verlag Berlin Heidelberg 2006 Printed in Germany The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Editor: Simon Rallison, Heidelberg Desk editor: Anne Clauss, Heidelberg Production editor: Nadja Kroke, Leipzig Cover design: design & production GmbH, Heidelberg Typesetting: LE-TEX Jelonek, Schmidt & Vöckler GbR, Leipzig Printed on acid-free paper SPIN 11332879 27/3150/YL – 5 4 3 2 1 0
Preface
Microbes are in our midst soon after birth. Thankfully, the number of harmless (and often beneficial) microbes far outnumber those that would do us harm. Our ability to ward off pathogens in our environment, including those that can colonize our exterior and/or interior surfaces, depends on the integrative action of the innate and adaptive immunity systems. This volume of CTMI, entitled Antimicrobial Peptides and Human Disease, is dedicated to the role of antimicrobial peptides (AMPs) in the innate host defense system of Homo sapiens. The concept that oxygen-independent killing systems of phagocytic cells is in part attributable to the antibiotic-like action of
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