Aptamers Selected by Cell-SELEX for Theranostics
This edited volume describes cell-SELEX as the fundamental tool used to generate aptamer molecules for a wide range of applications in molecular medicine, bioanalysis and chemical biology. Easily integrated into the natural heterogeneous cell matrix, apta
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tamers Selected by Cell-SELEX for Theranostics
Aptamers Selected by Cell-SELEX for Theranostics
Weihong Tan Xiaohong Fang •
Editors
Aptamers Selected by Cell-SELEX for Theranostics
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Editors Weihong Tan
Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha China
Xiaohong Fang Institute of Chemistry Chinese Academy of Sciences Beijing China
and Department of Chemistry University of Florida Gainesville, FL USA
ISBN 978-3-662-46225-6 DOI 10.1007/978-3-662-46226-3
ISBN 978-3-662-46226-3
(eBook)
Library of Congress Control Number: 2015931245 Springer Heidelberg New York Dordrecht London © Springer-Verlag Berlin Heidelberg 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer-Verlag GmbH Berlin Heidelberg is part of Springer Science+Business Media (www.springer.com)
Foreword
One of the great disappointments in chemistry over the past half-century has been the failure of theory to allow chemists to design molecules that bind specifically in aqueous solution to other molecules. This is, of course, the “medicinal chemistry problem”; a classical pharmaceutical is simply a molecule that binds to a protein target with a therapeutically interesting affinity, say a dissociation constant of less than one nanomolar. While heuristic processes are available to sort through hundreds of lead molecules to get dozens of hits that might generate single drug candidates ready for clinical trials, these rely on only broad theoretical concepts and, more frequently, chemical intuition, rarely on constructively detailed design. Even the three-dimensional molecular models for protein target that are now often routine thanks to modern crystallography have not delivered a definitive solution to this problem. The complexities of molecular interactions as well as the challenges of modeling the solvent in which they must occur continue t
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