Arabic Gum Grafted PEGDMA Hydrogels: Synthesis, Physico-Chemical Characterization and In-vitro Release of Hydrophobic Dr
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Article www.springer.com/13233 pISSN 1598-5032 eISSN 2092-7673
Arabic Gum Grafted PEGDMA Hydrogels: Synthesis, Physico-Chemical Characterization and In-vitro Release of Hydrophobic Drug Sani Mamman Ibrahim1,2 Teo Yin Yin*,1 Misni Misran1
1 2
Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia Department of Chemistry, Faculty of Sciences, Federal College of Education, Zaria, Nigeria Received July 5, 2020 / Revised September 7, 2020 / Accepted October 12, 2020
Abstract: Hydrogel development using natural and synthetic polymers for biomedical applications have shown promising properties for drug delivery due to virtuous stimuli response and improvement in mechanical strength. Biomaterial hydrogel was synthesized using combination of arabic gum (AG), a natural polymer and polyethylene glycol dimethacrylate (PEGDMA), a synthetic polymer. The synthesis process follows chemical cross linking by free radical polymerization. Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM) and differential scanning calorimetry (DSC) were used to characterize the hydrogels. Product yield, gel content and gelation time depends solely on the variable reacting concentrations and the mechanical properties of hydrogel depends on its compositions. Swelling studies reveal high swelling ratio in buffer solution pH 1.2 compare to buffer solution pH 7.4, and deionized water at pH 6.7. Swelling ratio raises with increase in PEGDMA concentration, but the presences of salt/ions solutions decreases the swelling ratio significantly and it depends on the charge of the ions. The kinetics of the swelling follows a second order non-linear rate equation. The rate of degradation revealed significant degradation in acidic medium and insignificant degradation was observed in basic medium. The encapsulation efficiency of quercetin introduced directly in the hydrogels during synthesis was found in the range of 85-94%. The release profile indicates the dependence of arabic gum grafted PEGDMA hydrogels on pH and compositions. The characteristic properties exhibited by the formulated hydrogels suggest the suitability of them to be applied as drug carriers. Keywords: hydrogel, arabic gum, PEGDMA, drug delivery, mechanical strength.
1. Introduction Three-dimensional polymeric network hydrogels are striking material platforms for biomedical applications because of their tissue like nature, biocompatibility, hydrophilicity and biomimetic characteristic properties.1 Drug transportation in the body system is a major concern in the medical and pharmaceutical industries. There are numerous carriers for drug delivery in the biomedical field and hydrogel is one of the most preferable carrier for safe drug delivery.2 Hydrogels as a carrier for drugs serve as protection to the drugs in the body system in addition to structural modification as a response to stimuli.3 Different synthesis methods of hydrogels have been applied in literature to control the chemical and mechanical properties o
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