Assessment of the Antimetastatic Activity of Extracts of Filipedula ulmaria Depending on Extractant
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Pharmaceutical Chemistry Journal, Vol. 54, No. 7, October, 2020 (Russian Original Vol. 54, No. 7, July, 2020)
ASSESSMENT OF THE ANTIMETASTATIC ACTIVITY OF EXTRACTS OF Filipedula ulmaria DEPENDING ON EXTRACTANT E. N. Amosova,1,* I. V. Shilova,1 E. P. Zueva,1 and O. Yu. Rybalkina1 Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 7, pp. 37 – 40, July, 2020.
Original article submitted June 16, 2020. Three extracts were produced from the above-ground part of the meadowsweet Filipendula ulmaria (L.) Maxim. using water, 40% ethanol, and 70% ethanol. Comparative assessment of their actions on the development of Lewis lung carcinoma (LLC) in C57Bl/6 mice showed that isolated administration led to inhibition of the development of the metastatic process by meadowsweet extracts prepared with water and 70% ethanol, with no effect on growth of the primary tumor. Comparative evaluation of the effects of meadowsweet extracts on the antitumor activity of cyclophosphamide (CP) in relation to primary tumors revealed no change in the efficacy of the cytostatic agent. Inclusion of meadowsweet extracts at doses of 25 and 50 mg/kg in the therapeutic regimen of mice with LLC produced significant increases in the antimetastatic action of CP using the aqueous extract (the indexes of inhibition of metastasis (IIM) were 75% and 98%). Meadowsweet extract prepared with 40% ethanol had no effect on the development of the tumor process in mice with LLC or the efficacy of CP treatment. Keywords: Filipendula ulmaria (L). Maxim extracts, Lewis lung carcinoma, cytostatic therapy.
The above-ground part and rhizomes of the meadowsweet Filipendula ulmaria (L). Maxim (Rosaceae family) are used in folk medicine as substances for the treatment of malignant neoplasms [1, 2]. Studies on models of tumors, both spontaneous and induced by chemical carcinogens or ionizing radiation, have demonstrated an anticancer action of decoctions of meadowsweet flowers [3 – 5]. In vitro experimental studies of aqueous (infusions, decoctions), methanolic, and aqueous-methanolic extracts of meadowsweet flowers have demonstrated inhibitory actions on the growth of human tumor cells (NCI-H460 Lewis lung carcinoma, A375-C5 melanoma, and MCF-7 breast adenocarcinoma), the most effective being the decoction [6]. Our previous studies showed that extracts of the above-ground parts of the meadowsweet in 70% ethanol given alone inhibited the development of metastases in mice with Lewis lung carcinoma, while coadministration with a cytostatic agent increases the antiblastoma activity of cyclophosphamide [7]. 1
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The aim of the present work was to study the effects of aqueous and aqueous-ethanolic (40% and 70%) extracts of the above-ground parts of the meadowsweet on the development of Lewis lung carcinoma in mice and the efficacy of cytostatic therapy. EXPERIMENTAL SECTION The above-ground parts of the meadowsweet Filipendula ulmaria (L.) Maxim. were collected in July 2018 in the flowering phase in the vicinity of Ol’govka village, Tomsk District. Air-dried material
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