Association between psoriasis, psoriatic arthritis and gastrointestinal disease
- PDF / 839,280 Bytes
- 8 Pages / 595 x 842 pts (A4) Page_size
- 16 Downloads / 232 Views
Wien Klin Wochenschr https://doi.org/10.1007/s00508-020-01740-8
Association between psoriasis, psoriatic arthritis and gastrointestinal disease An exploratory nationwide inpatient sample analysis Ahmed Yousaf · Rahul Raiker · Stephen M. Davis · Swapna Gayam · Zachary Zinn Received: 22 June 2020 / Accepted: 21 August 2020 © Springer-Verlag GmbH Austria, part of Springer Nature 2020
Summary Background Psoriasis is associated with cardiovascular disease, inflammatory bowel disease (IBD), metabolic syndrome, and psychiatric disease. Furthermore, psoriasis is associated with immune dysregulation and systemic inflammation. Objective To determine the association of psoriasis and psoriatic arthritis with IBD and the association of the combination of psoriasis or psoriatic arthritis with IBD and other gastrointestinal illnesses. Methods Discharge data from the 2000–2014 Nationwide Inpatient Sample, Healthcare Cost and Utilization Project (HCUP), which approximates a 20% stratified sample of all US hospitalizations, were analyzed. Multivariable logistic regression was used to examine the association between psoriasis and psoriatic arthritis with IBD and 23 gastrointestinal illnesses adjusting for sociodemographic characteristics. Results Psoriasis was associated with IBD (Crohn’s disease adjusted odds ratio (aOR) = 2.13, 95% confidence interval (CI) [2.0–2.3], p < 0.001). When adjustElectronic supplementary material The online version of this article (https://doi.org/10.1007/s00508-020-01740-8) contains supplementary material, which is available to authorized users. A. Yousaf, BA · R. Raiker, BS · Z. Zinn, MD () Department of Dermatology, West Virginia University, 64 Medical Center Drive, Morgantown, WV 26506, USA [email protected] S. M. Davis, PhD Department of Health Policy, Management & Leadership, West Virginia University, Morgantown, WV, USA Department of Emergency Medicine, West Virginia University, Morgantown, WV, USA S. Gayam, MD Department of Medicine, Section of Gastroenterology and Hepatology, West Virginia University, Morgantown, WV, USA
K
ing for sociodemographics and IBD, psoriasis was associated with 21 of 23 gastrointestinal diseases examined, most notably celiac disease, autoimmune hepatitis, and non-alcoholic fatty liver disease. Psoriatic arthritis was also associated with IBD (Crohn’s disease, aOR = 1.95, 95% CI [1.7–2.2], and ulcerative colitis, aOR = 2.66, 95% CI [2.4–2.9]). Conclusion Psoriasis and psoriatic arthritis inpatients have an associated increase in IBD and numerous other gastrointestinal illnesses. Keywords Crohn’s disease · Ulcerative colitis · Liver disease · Celiac disease · Cirrhosis
Introduction Psoriasis is a chronic, recurrent, immune-mediated inflammatory disorder with an estimated prevalence of 2–4% in western countries [1–3]. First presentation of psoriasis follows a bimodal distribution, peaking at ages 15–20 years and ages 55–60 years [4]. Psoriasis most commonly presents as well-defined, symmetric, erythematous plaques with silvery scale. Clinically benign skin from psoria
Data Loading...
