Longitudinal research on the bidirectional association between depression and arthritis
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ORIGINAL PAPER
Longitudinal research on the bidirectional association between depression and arthritis Chaofu Ke1 · Yanan Qiao1 · Siyuan Liu1 · Yuqi Rui2 · Ying Wu3 Received: 6 February 2020 / Accepted: 10 November 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Studies evaluating the mutual relation between depression and arthritis have been limited and yielded inconsistent results. The aim of this study was to investigate the bidirectional relationship between depression and arthritis in a middleaged and elderly Chinese population. Methods Participants ≥ 45 years of age were included from the China Health and Retirement Longitudinal Study (CHARLS). In stage I, we assessed the association of baseline depression with follow-up arthritis. In stage II, we examined whether the onset of arthritis predicted future depression. Logistic regression analyses were conducted to estimate the odds ratios (ORs) and confidence intervals (CIs) in stage I and stage II, respectively. Results In stage I, 24.3% (679/2794) of the depression group and 15.4% (1000/6482) of the non-depression group developed new arthritis cases. Compared with non-depression individuals, the risk of developing arthritis in depression patients was significantly higher (OR: 1.56, 95% CI 1.37–1.79). In stage II, 39.7% (973/2453) subjects in the arthritis group and 26.7% (1667/6236) subjects in the non-arthritis group developed depressive symptoms. The adjusted OR (95% CI) for depression in the arthritis group was 1.64 (1.45–1.86) times higher than that in the non-arthritis group. In the subgroup analyses according to sex, age, household income, residence, body mass index, smoking and drinking, all sub-groups yielded consistent associations. Conclusion The onset of depression increased the risk of incident arthritis; in addition, baseline arthritis predicted future depression in middle-aged and elderly Chinese adults. Keywords Depression · Arthritis · Bidirectional relationship · CHARLS
Introduction Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00127-020-01994-7) contains supplementary material, which is available to authorized users. * Ying Wu [email protected] 1
Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, People’s Republic of China
2
School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, People’s Republic of China
3
State Key Laboratory of Organ Failure Research, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, People’s Republic of China
Arthritis is a highly prevalent disease in midlife and late life worldwide. It is estimated that in 2010–2012, 22.7% of all US adults had doctor-diagnosed arthritis, and the prevalence is projected to reach 25.9% by 2040 [1]. In 2011, the prevalence of arthri
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