Association Between the hOGG1 1245C>G (rs1052133) Polymorphism and Susceptibility to Colorectal Cancer: a Meta-analys
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REVIEW ARTICLE
Association Between the hOGG1 1245C>G (rs1052133) Polymorphism and Susceptibility to Colorectal Cancer: a Meta-analysis Based on 7010 Cases and 10,674 Controls Yaser Ghelmani 1 & Fatemeh Asadian 2 & Mohammad Hossein Antikchi 3 & Seyed Alireza Dastgheib 4 & Seyed Hossein Shaker 5 & Jamal Jafari-Nedooshan 6 & Hossein Neamatzadeh 7,8 Accepted: 27 September 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background The 1245C>G (rs1052133) polymorphism of human 8-oxoguanine DNA glycosylase 1 (hOGG1) gene has been indicated to be correlated with colorectal (CRC) susceptibility, but studies have yielded conflicting results. Thus, the present meta-analysis was performed to derive a more precise estimation between hOGG1 1245C>G polymorphism and CRC risk. Methods Data were collected from several electronic databases such as PubMed, EMBASE, and Google Scholar databases, with the last search up to September 01, 2020. Pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to assess the strength of the association. Results A total of 24 case-control studies with 7010 CRC cases and 10,674 controls were selected. Pooled data showed that the hOGG1 1245C>G polymorphism was significantly associated with CRC risk under three genetic models, i.e., homozygote (GG vs. CC: OR = 1.229, 95% CI 1.031–1.465, p = 0.022); heterozygote (GC vs. CC: OR = 1.142, 95% CI 1.008–1.294, p = 0.037); and dominant (GG+GC vs. CC: OR = 1.162, 95% CI 1.034–1.304, p = 0.011). When stratified analysis by ethnicity, a significant association of the hOGG1 1245C>G polymorphism with risk of CRC was found in the Caucasians, but not in Asians. Moreover, there were significant associations between hOGG1 1245C>G polymorphism and CRC by PCR-RFLP and hospital-based subgroups. Conclusions Inconsistent with the previous meta-analysis, these meta-analysis results revealed that the hOGG1 1245C>G polymorphism might be associated with an increased risk of CRC, especially in Caucasians. Keywords Colorectal cancer . hOGG1 gene . Polymorphism . Meta-analysis
Introduction Colorectal cancer is one of the leading causes of cancer death worldwide, which its incidence and mortality in young adults has been increasing [1, 2]. Worldwide CRC is considered the
* Fatemeh Asadian [email protected] 1
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Clinical Research Development Center of Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran Department of Internal Medicine, Yazd Branch, Islamic Azad University, Yazd, Iran
third most common cancer and ranks second worldwide with regard to mortality [3, 4]. The global CRC burden by 2030 is estimated to have risen to more than 2.2 million new cases and 1.1 million deaths. There is a higher incidence of CRC, about two-thirds, in developed countries compared with developing
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Department of Medical Genetics, School of Medicine, Shiraz University of
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