The association between the poly(A) polymorphism in the VDR gene and cancer risk: a meta-analysis
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RESEARCH ARTICLE
The association between the poly(A) polymorphism in the VDR gene and cancer risk: a meta-analysis Jin Huang & Jiqiao Yang & Haichuan Wang & Tianyuan Xiong & Hongbo Zhang & Yaxian Ma & Xiaoze Wang & Jichong Huang & Liang Du Received: 12 February 2013 / Accepted: 25 February 2013 / Published online: 22 March 2013 # International Society of Oncology and BioMarkers (ISOBM) 2013
Abstract The poly(A) polymorphism (L/S) in the VDR gene has been implicated in susceptibility of cancer, but a number of studies have reported inconclusive results. The aim of this study is to investigate the relationship between the poly(A) polymorphism in the VDR gene and cancer risk by meta-analysis. We searched PubMed database, EMBASE database, CNKI database, and Wanfang database, covering all studies until January 22, 2013. Statistical analysis was performed by using the software Revman4.2 and STATA 10.0. A total 8,186 cancer cases and 8,685 controls in 19 case–control studies from 15 studies were identified for data analysis. The results suggested that the S allele carriers (SS+SL) did not have an increased or decreased risk of cancer when compared with the homozygote LL carriers (odds ratio (OR)=0.96, 95 % CI=0.87–1.06, P=0.43 for SS+SL vs. LL). In addition, in the subgroup analysis by ethnicity and cancer type, no significant association was found among Caucasians, African-Americans, prostate cancer, or breast cancer. This current meta-analysis suggested that the poly(A) polymorphism in the VDR gene may not contribute to the risk of cancer. Future studies are needed to validate our findings. Electronic supplementary material The online version of this article (doi:10.1007/s13277-013-0724-0) contains supplementary material, which is available to authorized users. J. Huang : J. Yang : H. Wang : T. Xiong : Y. Ma : X. Wang : J. Huang West China Medical School/West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China H. Zhang The Second Medical School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610000, China L. Du (*) The Periodical Press of West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China e-mail: [email protected]
Keywords Vitamin D receptor . Poly(A) . Polymorphism . Cancer . Meta-analysis
Introduction It is well known that cancer is the result of a process of unregulated cell growth [1]. Factors involved in the cell growth regulation and proliferation may be important in the etiology of cancer [2]. There have been many studies suggesting that growth hormones are important in the etiology of caner, and one of the most important growth factors is vitamin D receptor. Vitamin D receptor is a very important nuclear receptor involved in the regulation of many physiological processes, including cell growth, differentiation, and stabilization of metabolic homeostasis [3, 4]. VDR activates its physiological effects by the vitamin D metabolite, 1,25(OH)D3. Several studies suggested that VDR might also be involved in insulin and insulin-like growth factor mediate
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