Association between the rs3751143 polymorphism of P2RX7 gene and chronic lymphocytic leukemia: A meta-analysis
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REVIEW ARTICLE
Association between the rs3751143 polymorphism of P2RX7 gene and chronic lymphocytic leukemia: A meta-analysis Wen-Jun Zhang 1 & Zheng-Ming Zhu 1 Received: 1 June 2020 / Accepted: 15 September 2020 # Springer Nature B.V. 2020
Abstract Objectives Meta-analysis was used to determine the association between rs3751143 polymorphism of P2RX7 gene and the risk of chronic lymphocytic leukemia (CLL). Methods Search for published articles about the association between the rs3751143 and CLL in PubMed, MEDINE, Web of Science, and Embase databases, with a calculated odds ratio of (OR) and 95% confidence interval (95%CI). Results A total of 1184 cases and 1725 controls in 8 studies were pooled together for evaluation of the overall association between rs3751143 and risk of CLL. Allele model (A vs C, p = 0.16, OR = 0.85, 95%CI = 0.71–1.17), homozygous model (AA vs CC, p = 0.07; OR = 0.78, 95%CI = 0.84–1.08), and heterozygous model (AC vs CC, p = 0.76; OR = 0.85; 95%CI = 0.68– 0.79) did not show decreased risk of developing CLL. Similarly, dominant model (AA + AC vs. CC: p = 0.58; OR = 1.10, 95%CI = 0.69–1.75), and recessive model (AA vs AC + CC, p = 0.21, OR = 1.18, 95%CI = 0.70–1.99) failed to show decreased risk of developing CLL. However, in familial, heterozygous model (AC vs. CC: p = 0.0006, OR = 0.64, 95%CI = 0.67–1.50) and recessive model (AA vs. AC + CC: p = 0.0017; OR = 1.02, 95%CI = 0.73–2.35) indicated the association between the inheritance of rs3751143 and the risk of developing CLL. In the overall survival prognosis, no significant association between rs3751143 and CLL was detected with relatively high heterogeneity. Conclusions Our pooled data indicates that there is a correlation between the inheritance of rs3751143 and the risk of CLL in familial. Keywords P2X7 receptor (P2RX7) . rs3751143 polymorphism . Chronic lymphocytic leukemia . Meta-analysis
Introduction Chronic lymphocytic leukemia (CLL) is a malignant tumor occurring in the blood system, which is difficult to treat clinically. The diagnosed patients are mainly treated by chemotherapy but also by radiation therapy, immunotherapy (such as interferon, anti-CD20 monoclonal antibodies, and anti-CD52 antibodies) and hematopoietic stem cell transplantation, but it is easy to relapse [1, 2]. Therefore, it is necessary to explore the relevant molecular factors in the pathogenesis of CLL, and better targeted and individualized treatment. P2RX7 is dependent on ATP ion channel receptor, and ATP is a natural activator of P2RX7. When the body is subjected to noxious * Zheng-Ming Zhu [email protected] 1
The Second Affiliated Hospital, Nanchang University, Nanchang 343000, Jiangxi, China
stimulation, high concentration of extracellular ATP can activate P2RX7, opens the ion channels on the cell membrane (mainly calcium ion influx), changes the permeability of the cell membrane, and affects the molecular metabolism in the cell [3]. P2RX7 is widely expressed in blood-derived cells (such as lymphocytes, macrophages, bone marrow-derived cells). Activation o
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