Association of arterial stiffness with the histological severity of nonalcoholic fatty liver disease
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ORIGINAL ARTICLE
Association of arterial stiffness with the histological severity of nonalcoholic fatty liver disease Hack‑Lyoung Kim1 · Bo Kyung Koo2 · Sae Kyung Joo3 · Won Kim3 Received: 5 September 2020 / Accepted: 9 November 2020 © Asian Pacific Association for the Study of the Liver 2020
Abstract Background Although arterial stiffness has been reported to be associated with nonalcoholic fatty liver disease (NAFLD), previous studies have relied only on noninvasive assessments for the diagnosis of NAFLD. This study attempted to investigate the association of arterial stiffness with the histological severity of NAFLD. Methods We analyzed data from a biopsy-proven prospective NAFLD cohort. Augmentation index corrected for a heart rate of 75 bpm (AI@75) was obtained using applanation tonometry of the radial artery. Results A total of 154 patients (mean age 55.2 years; females 55.8%) with biopsy-proven NAFLD were analyzed. Patients with higher AI@75 (≥ 76%) showed more severe grades of lobular and portal inflammation and hepatocellular ballooning, and more advanced stages of fibrosis compared to those with lower AI@75 ( 20 g/day in females), and (6) diagnosis of malignancy within the past year. Among the eligible study participants, those with at least two of the following risk factors underwent liver biopsy: (1) diabetes mellitus, (2) central obesity (waist circumference ≥ 90 cm for males and ≥ 80 cm for females) [19, 20], (3) a high level of triglycerides (≥ 150 mg/ dL), (4) a low level of high-density lipoprotein (HDL) cholesterol (
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