Association of brain white matter lesions with arterial stiffness assessed by cardio-ankle vascular index. The Beijing V
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ORIGINAL RESEARCH
Association of brain white matter lesions with arterial stiffness assessed by cardio-ankle vascular index. The Beijing Vascular Disease Evaluation STudy (BEST) Huan Liu 1 & Jinbo Liu 1 & Hongwei Zhao 1 & Hongyu Wang 1 & for the BEST research group
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background—The association of brain white matter lesions with arterial stiffness, as assessed by the cardio-ankle vascular index, is not well characterized in the population. Objective: The aim of this study was to quantify the cross-sectional association of brain white matter lesions with arterial stiffness assessed by the cardio-ankle vascular index among 1176 adults. Methods: We used logistic regression to evaluate the associations of the cardio-ankle vascular index with brain white matter lesions, detected by computed tomography or magnetic resonance imaging, versus normal brain white matter. Results: After adjustment for age, sex, systolic blood pressure, blood lipid level, C reactive protein level, homocysteine level, uric acid level, urea nitrogen level, creatinine level, hypertension, diabetes, coronary artery disease, peripheral artery disease, and stroke, the multivariable analysis showed that age, sex, systolic blood pressure, stroke and the cardio-ankle vascular index were independently associated with the presence of brain white matter lesions. Age range (odds ratio: from 2.48 to 33.64, all p < 0.05) showed the strongest association, followed by stroke (odds ratio: 7.16, 95% confidence interval: 4.59 to 11.16), male sex (odds ratio: 1.80, 95% confidence interval: 1.18 to 2.75), cardio-ankle vascular index (odds ratio: 1.26, 95% confidence interval: 1.06 to 1.50) and systolic blood pressure (odds ratio: 1.01, 95% confidence interval: 1.00 to 1.02). Conclusion: Higher arterial stiffness assessed by the cardioankle vascular index was associated with the presence of brain white matter lesions. Longitudinal characterization of the observed associations is warranted to assess whether arterial stiffness predicts brain white matter lesions. Keywords Arterial stiffness . Cardio-ankle vascular index (CAVI) . Brain white matter lesions
Abbreviations BMI Body mass index BUN Urea nitrogen CAD Coronary artery disease CAVI Cardio-ankle vascular index Cr Creatinine CRP C reactive protein DBP Diastolic blood pressure FPG Fasting plasma glucose Hcy Homocysteine
HDL-C LDL-C HR HT PAD SBP TC TG UA WMLs
* Hongyu Wang [email protected]
Introduction
1
Vascular Medicine Center, Peking University Shougang Hospital, NO.9, Jinyuanzhuang Road, Shijingshan District, Beijing 100144, China
High-density lipoprotein cholesterol Low-density lipoprotein cholesterol Heart rate Hypertension Peripheral artery disease. Systolic blood pressure Total cholesterol Triglyceride Uric acid White matter lesions
Arterial stiffness is emerging as a marker of arterial aging and cardiovascular disease and serves as a risk marker for incident mild cognitive impairment (Pase et al. 2016; Zeki Al Ha
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