The severity and extent of periodontitis is associated with cardio-ankle vascular index, a novel arterial stiffness para
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ORIGINAL ARTICLE
The severity and extent of periodontitis is associated with cardio-ankle vascular index, a novel arterial stiffness parameter Kansurang Chansawang 1 & Attawood Lertpimonchai 1,2 & Nisachon Siripaiboonpong 1,2 & Lalitsara Thienpramuk 3 & Prin Vathesatogkit 4 & Thosaphol Limpijankit 4 & Orawan Charatkulangkun 1,2 Received: 24 June 2020 / Accepted: 29 October 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Objectives To evaluate the association between the severity and extent of periodontitis and arterial stiffness using the cardioankle vascular index (CAVI). Materials and methods A cross-sectional study of 2888 Electricity Generation Authority of Thailand (EGAT) employees aged 44–78 years was conducted. The severity of periodontitis was evaluated based on mean clinical attachment level (CAL). The percentage of sites with CAL ≥ 5 mm was used to divide the extent of periodontitis into healthy (0%), localized (> 0–< 30%), and generalized (≥ 30%). The CAVI value, a novel blood pressure-independent arterial stiffness parameter, was analyzed as both continuous and categorical data (low: < 9 or high: ≥ 9). Regression analysis was used to estimate the level of association. Results The participants demonstrated a mean CAL, % sites with CAL ≥ 5 mm, and a CAVI value of 3.2 ± 1.2 mm, 16.0 ± 20.8%, and 8.24 ± 1.12, respectively. Higher mean CAVI was observed with greater mean CAL and % sites with CAL ≥ 5 mm. The mean CAVI of the healthy, localized, and generalized periodontitis groups were 8.01 ± 1.11, 8.22 ± 1.12, and 8.51 ± 1.04, respectively (p < 0.01). Linear and logistic regression analysis demonstrated a significant relationship between CAVI and all periodontal variables with β = 0.004–0.17 and OR = 1.01–1.58, respectively. Conclusions There is a significant dose-dependent association between the severity and extent of periodontitis and arterial stiffness measured by CAVI in Thai adults. Clinical relevance Preventing arterial stiffness, an early sign of cardiovascular events, by controlling the emerging risk factors, such as periodontitis, might have a high impact on health promotion. Keywords Arterial stiffness . Cardiovascular disease . CAVI . Periodontitis
* Orawan Charatkulangkun [email protected] Kansurang Chansawang [email protected]
Thosaphol Limpijankit [email protected] 1
Department of Periodontology, Faculty of Dentistry, Chulalongkorn University, 34 Henri-Dunant Road, Pathumwan, Bangkok 10330, Thailand
2
Center of Excellence in Periodontal Disease and Dental Implant, Chulalongkorn University, Bangkok 10330, Thailand
3
Electricity Generating Authority of Thailand, Nonthaburi 11130, Thailand
4
Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
Attawood Lertpimonchai [email protected] Nisachon Siripaiboonpong [email protected] Lalitsara Thienpramuk [email protected] Prin Vathesatogkit [email protected]
Clin Oral Invest
Introduction Periodontitis is a chronic inflammatory disease characterized by destruction
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