Associations of B-type natriuretic peptide (BNP) and dialysis vintage with CMRI-derived cardiac indices in stable hemodi
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ORIGINAL PAPER
Associations of B‑type natriuretic peptide (BNP) and dialysis vintage with CMRI‑derived cardiac indices in stable hemodialysis patients with a preserved left ventricular ejection fraction Xiaoyu Han1,2 · Fangfang He3 · Yukun Cao1,2 · Yumin Li1,2 · Jin Gu1,2 · Heshui Shi1,2 Received: 11 December 2019 / Accepted: 13 July 2020 © Springer Nature B.V. 2020
Abstract To assess left ventricular myocardial native T1/T2 values and systolic strain and their associations with B-type natriuretic peptide (BNP) and dialysis vintage in hemodialysis (HD) patients with a preserved left ventricular ejection fraction (LVEF). Forty-three HD patients with end-stage renal disease (ESRD) but a preserved LVEF (≥ 50%) and 28 healthy volunteers were enrolled. BNP was measured at the time of cardiac magnetic resonance (CMR) measurements. Global native T1 and T2 values were significantly higher in the HD patients (native T1: 1056 ± 32 ms vs. 1006 ± 25 ms, p < 0.001; T2: 50 ± 3 ms vs. 46 ± 2 ms, p < 0.001) than in the controls. The mean peak global circumferential strain (GCS) and global longitudinal strain (GLS) were both significantly reduced in the HD patients compared with the controls (GCS: − 13 ± 3 vs. − 16 ± 3, p < 0.001; GLS: − 12 ± 4 vs. − 15 ± 3, p = 0.001). In the HD patients, the global native T1 value showed a positive correlation with the global T2 value (r = 0.311, p = 0.042) and significant correlations with GCS (r = 0.564, p < 0.001) and GLS (r = 0.359, p = 0.018). Significant positive correlations were found between lg BNP levels and T2 values (r = 0.569, p < 0.0001) and the left atrial volume index (LAVI) (r = 0.536, p = 0.012). GLS showed significant positive correlations with the LVMI (r = 0.354, p = 0.020) and dialysis vintage (p = 0.026; r = − 0.339) in the HD patients. HD patients with a preserved LVEF have increased native T1/T2 values and decreased strain compared to controls. T2 values and the LVAI were positively associated with BNP in HD patients. Keywords Cardiovascular disease · Hemodialysis · Magnetic resonance imaging · Strain · Fibrosis
Introduction
Xiaoyu Han and Fangfang He contributed equally to the work. * Heshui Shi [email protected] Xiaoyu Han [email protected] Fangfang He [email protected] Yukun Cao [email protected] Yumin Li [email protected]
Chronic kidney disease (CKD) and end-stage renal disease (ESRD) have high mortality rates despite significant advances in hemodialysis (HD), and cardiovascular disease (CVD) is a major cause of morbidity and mortality in HD 1
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Rd, Wuhan, Hubei Province 430022, People’s Republic of China
2
Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, People’s Republic of China
3
Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Rd, Wuhan, Hubei Province 430022, People’s Republic of China
Jin Gu gujin‑[email protected]
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