Faecal calprotectin in hidradenitis suppurativa: a study of 55 patients
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a Supplementary data (Table S1) associated with this article can be found, in the online version, at doi:10.1684/ejd.2020.3815.
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Department of Dermatology, Department of Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510 Japan
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Hind AL-BUSANI1 Takeshi NAMIKI1 Yusuke YOSHIOKA1 Tsukasa UGAJIN1 Keiko MIURA2 Hiroo YOKOZEKI1
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Faecal calprotectin in hidradenitis suppurativa: a study of 55 patients Hidradenitis suppurativa (HS) is a chronic inflammatory disorder with cutaneous expression that might be associated with inflammatory bowel disease (IBD) [1-3]; Dermatologists should inquire about gastrointestinal (GI) symptoms whenever a patient with HS consults [2]. Calprotectin is a 36-KDalton protein mainly derived from neutrophils, which has antimicrobial effects as well as a role within the innate immune response [4]. Measurement of faecal calprotectin (FC) is currently used by gastroenterologists as a non-invasive surrogate biomarker for detecting intestinal inflammation. FC may help distinguish IBD from functional conditions, although it is not fully specific [5, 6]. A recent study showed higher levels of FC in patients with psoriatic arthritis than those with psoriasis [7]. Data on FC levels in patients with HS and available evidence to determine whether FC screening is useful or not is currently lacking. We aimed to investigate, in a retrospective study, the association between FC levels and HS determinants (in particular, age, severity of disease, and associated inflammatory comorbidities). This study was performed in two centres (in Helsinki, Finland and Tours, France), on all patients who had consulted for HS between February and June 2019, for whom first morning stool samples were systematically analysed. Demographic and clinical data were collected. Calprotectin level in stools was quantified by ELISA immunoassay (Calpro AS, Norway) using an automatic analyser (DS2, Dynex, USA) in Finland and with particle-enhanced turbidic immunoassay (Bühlmann Laboratories, Switzerland) and the Cobas c501/502 automated analyser (Roche Diagnostics, France) in France. The limit EJD, vol. 30, n◦ 4, July-August 2020
Table 1. Univariate analysis of variables associ
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